A distributed reservation-based multiple access protocol is proposed, analyzed and evaluated. This scheme is based on the quasi-orthogonality property that can be achieved through the use of spread spectrum signaling, which permits the correct reception of a signal despite the simultaneous presence of other channel users. The effect on performance of the ability to tolerate varying levels of other-user interference is demonstrated. No acknowledgment or feedback information from the destination is required, nor is any form of coordination among the users necessary.