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    EFFECT OF ANTHOCYANIN-RICH EXTRACTS ON 5-FLUROURACIL CHEMOTHERAPY

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    No. of downloads: 2627

    Date
    2006-01-24
    Author
    su, ye
    Advisor
    Magnuson, Bernadene
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    Abstract
    Anthocyanins are natural colorants, with potential chemopreventive activity. 5-Flurouracil (5-Fu) is a widely used cancer chemotherapeutic drug. However, it has serious side effects. Objective: To determine whether anthocyanin-rich-extracts (ARE) can increase the effectiveness of 5-Fu. Methods: Colon cancer cells were treated with ARE in combination with 5-Fu to assess in vitro whether ARE would enhance 5-Fu cytotoxicity. In vivo, rats were given diets with or without ARE for 14 days. On day 11, rats were injected with either 5-Fu or its vehicle. Total blood cells counts and pathological analyses were conducted. Results: ARE enhanced the growth inhibition by 5-Fu in colon cancer cell lines, but almost had no effect on normal colon cells. 5-Fu had serious side effects on the rats. Dietary ARE partially reduced the gastrointestinal damage by 5-Fu. Further studies with advanced tumor models are needed to assess effect of ARE on 5-Fu tumor inhibition in vivo.
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    http://hdl.handle.net/1903/3320
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    • Nutrition & Food Science Theses and Dissertations
    • UMD Theses and Dissertations

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