PRELIMINARY GENETIC CHARACTERIZATION OF RIBOSOMAL PROTEIN L10 IN SACCHAROMYCES CEREVISIAE
Simmons, Mary Kecia Rigsby
Dinman, Jonathan D
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While recent research has focused on the exciting concept of the ribosome as a ribozyme, ribosomal proteins have been largely overlooked. This study focuses on four previously identified mutants of the ribosomal large subunit protein L10, in an effort to better understand how the protein's structure corresponds to its function. All of the mutants studied displayed how the embedded nature of L10 caused only slight conformational changes to impact function of the ribosome as a whole; in these cases primarily altering the interaction between the ribosomal A-site and aminoacyl-tRNAs.