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A COMBINATORIAL DESIGN OF A PROTEIN-BINDING DNA MICROARRAY

dc.contributor.advisorHunt, Brian R.en_US
dc.contributor.authorQureshi, Aaron M.en_US
dc.date.accessioned2005-02-02T06:41:46Z
dc.date.available2005-02-02T06:41:46Z
dc.date.issued2004-11-29en_US
dc.identifier.urihttp://hdl.handle.net/1903/2081
dc.description.abstractThe biological process of transcription creates from a template DNA strand (i.e., the gene) copies of short-lived mRNA. The amount of mRNA produced determines the gene's expression in the cell, which affects the activity of the gene at a given time. Transcription factors are proteins which bind to the DNA in the neighborhood of the gene in order to regulate the location and rate of transcription. An important biological question is therefore to find binding locations and binding strengths for transcription factors. This has traditionally been a laborious experimental process, but a new technology called a protein-binding microarray allows us to assay the binding affinities of a given transcription factor for many different DNA sequences in parallel. This thesis addresses a suitable combinatorial design for these microarrays that is both effective and economical.en_US
dc.format.extent197655 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.titleA COMBINATORIAL DESIGN OF A PROTEIN-BINDING DNA MICROARRAYen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentMathematicsen_US
dc.subject.pqcontrolledMathematicsen_US
dc.subject.pqcontrolledBiology, Geneticsen_US
dc.subject.pquncontrolledmicroarrayen_US
dc.subject.pquncontrolledshift registeren_US
dc.subject.pquncontrolledtranscriptionen_US
dc.subject.pquncontrolledprotein-bindingen_US
dc.subject.pquncontrolledtranscription factoren_US
dc.subject.pquncontrolledDe Bruijnen_US


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