The purpose of this research was to examine the effects of interactive whiteboard instruction on early numeracy skills of students with Autism Spectrum Disorders (ASD). Four students diagnosed with ASD between the ages of five to seven years old participated. They were taught early numeracy skills, specifically one-to-one correspondence and representation of numbers, using an interactive whiteboard (IAW) and discrete trial training (DTT). A multiple probe design across subjects was used to determine the effectiveness of the IAW instruction. It was predicted that students with ASD would acquire, maintain, and generalize the early numeracy skills taught using the IAW. Results revealed the IAW with DTT was effective for teaching early numeracy skills to students with ASD. The introduction of the intervention resulted in all participants meeting the established criteria. All students generalized the target early numeracy skills to a different setting and with different materials and the results were maintained over time. The findings of the study support the effectiveness of the IAW, coupled with DTT, to teach early numeracy skills to students with ASD. This study met the evidence standards for single case design addressed by What Works Clearinghouse. Implications for practice include the consideration of using the IAW to teach a variety of academic skills as well as developing interactive lessons based on each student’s needs. Future research should focus on generalization of skills gained using IAW instruction.