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    THERMODYNAMICS AND APPLICATION OF A PAIR OF SYNTHETIC NUCLEOBASES FROM ARTIFICIALLY EXPANDED GENETIC INFORMATION SYSTEM

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    Wang_umd_0117E_17353.pdf (20.81Mb)
    No. of downloads: 80

    Date
    2016
    Author
    Wang, Xiaoyu
    Advisor
    Kahn, Jason D
    DRUM DOI
    https://doi.org/10.13016/M2TB9Z
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    Abstract
    UV-melting experiments were performed on 9-mer duplexes containing a pair of synthetic nucleobases P·Z, two members of Expanded Genetic Information System (AEGIS), or P, Z containing mismatches. Enthalpy, entropy and free energy change were derived from simulation using two-state transition model. Nearest neighbor thermodynamic parameters of trimers or tetramers containing P·Z pair or P, Z containing mismatches were derived based on known nearest neighbor parameters. Proposed structures based on thermodynamic parameters are discussed. An application using P·Z pair as reverse selection tool of desired nucleic acid secondary structure is described.
    URI
    http://hdl.handle.net/1903/18690
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    • Chemistry & Biochemistry Theses and Dissertations
    • UMD Theses and Dissertations

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    DRUM is brought to you by the University of Maryland Libraries
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