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The Effect of Dietary Tartrazine on Brain Dopamine and the Behavioral Symptoms of Attention Deficit Hyperactivity Disorder

dc.contributor.advisorCastonguay, Thomas W.
dc.contributor.authorBloom, Shoshana
dc.contributor.authorChiang, Kevin
dc.contributor.authorDemehri, Sharlene
dc.contributor.authorKreshpanji, Sara
dc.contributor.authorMcCaffrey, Erin
dc.contributor.authorPatel, Karishma
dc.contributor.authorSebastian, Tracy
dc.contributor.authorShan, Salwa
dc.contributor.authorSukri, Leah
dc.date.accessioned2016-06-15T15:05:11Z
dc.date.available2016-06-15T15:05:11Z
dc.date.issued2016-05
dc.identifierhttps://doi.org/10.13016/M2VB64
dc.identifier.urihttp://hdl.handle.net/1903/18096
dc.description.abstractAttention Deficit Hyperactivity Disorder is a neurodevelopmental disorder correlated with a decrease in brain dopamine and an increase in behavioral symptoms of hyperactivity and impulsivity. This experiment explored how tartrazine (Yellow #5) impacts these symptoms. After tartrazine administration to Spontaneously Hypertensive Rats (SHR), dopamine concentrations in regions of brain tissue were measured using Enzyme-Linked Immunosorbent Assay analysis. Behavioral testing with a T-maze and open field test measured impulsivity and hyperactivity, respectively. Results indicate that dietary tartrazine increases hyperactive behaviors in the SHR. However, results do not indicate a relationship between dietary tartrazine and brain dopamine. No conclusions regarding the relationship between dietary tartrazine and impulsivity were drawn.en_US
dc.language.isoen_USen_US
dc.subjectGemstone Team ATTENTen_US
dc.subjectAttention Deficit Hyperactivity Disorderen_US
dc.subjecttartrazineen_US
dc.subjectbrain dopamine
dc.titleThe Effect of Dietary Tartrazine on Brain Dopamine and the Behavioral Symptoms of Attention Deficit Hyperactivity Disorderen_US
dc.typeThesisen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)


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