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    The Effect of Dietary Tartrazine on Brain Dopamine and the Behavioral Symptoms of Attention Deficit Hyperactivity Disorder

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    No. of downloads: 1284

    Date
    2016-05
    Author
    Bloom, Shoshana
    Chiang, Kevin
    Demehri, Sharlene
    Kreshpanji, Sara
    McCaffrey, Erin
    Patel, Karishma
    Sebastian, Tracy
    Shan, Salwa
    Sukri, Leah
    Advisor
    Castonguay, Thomas W.
    DRUM DOI
    https://doi.org/10.13016/M2VB64
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    Abstract
    Attention Deficit Hyperactivity Disorder is a neurodevelopmental disorder correlated with a decrease in brain dopamine and an increase in behavioral symptoms of hyperactivity and impulsivity. This experiment explored how tartrazine (Yellow #5) impacts these symptoms. After tartrazine administration to Spontaneously Hypertensive Rats (SHR), dopamine concentrations in regions of brain tissue were measured using Enzyme-Linked Immunosorbent Assay analysis. Behavioral testing with a T-maze and open field test measured impulsivity and hyperactivity, respectively. Results indicate that dietary tartrazine increases hyperactive behaviors in the SHR. However, results do not indicate a relationship between dietary tartrazine and brain dopamine. No conclusions regarding the relationship between dietary tartrazine and impulsivity were drawn.
    URI
    http://hdl.handle.net/1903/18096
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    DRUM is brought to you by the University of Maryland Libraries
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