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Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010

dc.contributor.advisorDallal, Cher Men_US
dc.contributor.authorHaque, Mefruz Salwaen_US
dc.date.accessioned2015-07-17T05:35:48Z
dc.date.available2015-07-17T05:35:48Z
dc.date.issued2015en_US
dc.identifierhttps://doi.org/10.13016/M2SD19
dc.identifier.urihttp://hdl.handle.net/1903/16802
dc.description.abstractPhthalates, commonly used to make plastics more durable, are a group of endocrine disrupting chemicals (EDC), with potential for adverse metabolic consequences. Associations between exposure to 13 phthalate metabolites and the prevalence of metabolic syndrome (MetS) were examined among 5,409 U.S adults &#8805; 18 years of age, who participated in the National Health and Nutrition Examination Survey from 2005-2010. MetS was assessed using clinical and questionnaire data. Odds Ratio (OR) and 95% Confidence Intervals (CI) adjusting for age, creatinine and key confounders, were estimated with multivariable logistic regression. Positive associations were observed between individual phthalate metabolites and MetS: (MCOP OR=1.31, 95% CI=1.40, 1.64, p-trend<.01; MCPP OR=1.39, 95% CI=1.09, 1.77, p-trend=0.01). In gender stratified analyses, findings with MCOPP and MCPP were restricted to women only. Phthalate metabolites may increase the prevalence of MetS; however, further studies are needed to better understand the role of EDCs in the development of MetS.en_US
dc.language.isoenen_US
dc.titleAssociations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010en_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentEpidemiology and Biostatisticsen_US
dc.subject.pqcontrolledEpidemiologyen_US
dc.subject.pqcontrolledEnvironmental healthen_US
dc.subject.pquncontrolledepidemiologyen_US
dc.subject.pquncontrolledmetabolic syndromeen_US
dc.subject.pquncontrolledmetabolitesen_US
dc.subject.pquncontrolledNHANESen_US
dc.subject.pquncontrolledphthalatesen_US


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