The University of Maryland's Jeong H. Kim Engineering Building is a state-of-the-art academic research facility. This thesis describes an energy analysis and simulation study that serves to identify energy saving opportunities and optimum operation of the building to achieve its goals of high energy efficiency and substantial CO2 emission reduction. A utility analysis, including a benchmarking study, was completed to gauge the performance of the facility and a detailed energy model was developed using EnergyPlus to mimic current operation. The baseline energy model was then used to simulate eight energy efficiency measures for a combined energy savings of 16,760 MMBtu, reducing annual energy use by 25.3%. The simple payback period for the proposed measures as a single project is estimated to be less than one year. Due to the high-tech and unique usage of the Kim Engineering Building, including cleanrooms and research labs, this thesis also contributes to the development of energy consumption benchmarking data available for such facilities.