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The role of the adherens junction protein alphaN-catenin in neural crest-derived trigeminal ganglia formation

dc.contributor.advisorTaneyhill, Lisaen_US
dc.contributor.authorHooper, Rachelen_US
dc.description.abstractNeural crest cells (NCCs), a transient, multipotent population of cells that arise during neurulation, are a class of cells crucial to normal vertebrate development. NCCs must be tightly regulated by molecular and structural cues to de-adhere from the neural tube, migrate to their final destinations in the developing embryo, and differentiate to contribute to a variety of structures throughout the adult body. αN-catenin is the neural subtype of an adherens junction protein found in the apical region of premigratory NCCs, and plays an important role in controlling early phases of NCC migration. Although down-regulation of αN-catenin is critical for initial stages of NCC migration, the functional role of αN-catenin in later NCC migration and differentiation remains elusive. In this study, we investigate the spatio-temporal expression pattern of αN-catenin and elucidate effects on NCC movement and contribution to the trigeminal ganglia after perturbation of αN-catenin in the premigratory NCC population.en_US
dc.titleThe role of the adherens junction protein alphaN-catenin in neural crest-derived trigeminal ganglia formationen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentAnimal Sciencesen_US
dc.subject.pqcontrolledDevelopmental biologyen_US
dc.subject.pqcontrolledMolecular biologyen_US
dc.subject.pquncontrolledadherens junctionsen_US
dc.subject.pquncontrolledneural cresten_US

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