This study examined a comprehensive stress-buffering model in a sample of 200 college students. Specifically, this study looked at social support and optimism as moderators between different types of stress and psychological health while controlling for gender given prior research that has demonstrated gender differences among the study constructs. Hierarchical regression analyses found that social support, but not optimism, worked as a significant moderator between different stressors, developmental challenge stress, time pressure stress, and social mistreatment stress, and psychological health. Supplemental analyses found in an independent samples t-test analysis that female college students had higher mean levels of time pressure stress than male college students. An extensive literature review of the study constructs including conceptual and methodological information and areas of improvement are delineated. Limitations of this study as well as future directions in research and clinical practice are also included.