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dc.contributor.advisorBentley, William Een_US
dc.contributor.authorParmar, Anupreeten_US
dc.date.accessioned2010-07-03T05:38:32Z
dc.date.available2010-07-03T05:38:32Z
dc.date.issued2010en_US
dc.identifier.urihttp://hdl.handle.net/1903/10475
dc.description.abstractA comprehensive model for calculating pH and conductivity values for a buffer solution added to the eluate of a cation exchange column at Bayer Healthcare has been developed. Bayer Healthcare's Berkeley facility manufacturess Kogenate - a drug for Hemophilia. This project was carried out at one of the intermediate purification steps of Kogenate, where the pH and conductivity of a buffer solution added to a chromatographic column's eluate has to be critically adjusted. Currently this process is done manually and requires two operators. In order to reduce the manual labor as well as improve accuracy, an automation model was developed using feedback control and Bayer's pH and conductivity predicting empirical correlations.en_US
dc.titleAUTOMATION MODEL FOR pH AND CONDUCTIVITY ADJUSTMENT FOR A CATION EXCHANGE COLUMN ELUATE BUFFERen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentChemical Engineeringen_US
dc.subject.pqcontrolledChemistry, Generalen_US


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