Family Science

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Formerly known as the Department of Family Studies.

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    THE INTERGENERATIONAL TRANSMISSION AND IMPACTS OF ADVERSE CHILDHOOD EXPERIENCES
    (2024) McConnell, Krystle; Shenassa, Edmond; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Evidence that adverse childhood experiences (ACEs) are associated with a wide range of adverse health and behavioral outcomes, including poor behavioral outcomes, and increased substance use, has been expanded to demonstrate that ACEs may be a determinant in adverse health and behavioral outcomes across generations as well. To disentangle the intergenerational impacts of ACEs on select health and behavioral outcomes and inform future intergenerational research and practice, three separate studies were conducted as part of this investigation. The first is a systematic review assessing whether ACEs predict earlier age of initiation differently depending on substance, conducted to inform timing of ACE screening and substance use intervention within generations. Given evidence to suggest that maternal ACEs predict related behavioral outcomes, the association between ACEs and earlier age of substance use may extend across generations as well. Informed by the first study, the second study in this investigation assesses the association between maternal ACEs and offspring age of alcohol initiation. Because offspring concordant for higher intergenerational ACE exposure may be most susceptible to the intergenerational impacts of adversity, this study also assesses whether the association between maternal ACEs and offspring age of alcohol initiation is different depending on offspring ACE exposure. The third study of this investigation assesses the association between maternal ACEs and internalizing and externalizing behavior. Importantly, the well-established intergenerational continuity of adversity was considered conceptually and methodologically for the latter two studies. If there is a direct association of maternal ACEs on offspring outcomes independent of offspring ACEs, then ACE screening and intervention efforts should be expanded to include and consider maternal ACEs in addition to offspring ACEs. Therefore, the controlled direct effect of maternal ACEs, not through offspring ACEs, was estimated. Findings from the first study suggest that while ACEs are associated with earlier age of alcohol, nicotine, marijuana, and opioid initiation, often in a dose-dependent manner, ACEs may predict earlier initiation of alcohol and nicotine relative to other substances assessed. Three or more ACEs were associated with initiation of alcohol across multiple studies, with effect sizes (OR) ranging from 1.9 (95% CI: 1.7, 2.1) to 6.2 (95% CI: 4.6, 8.3). Among the youngest samples included in this review (aged 9-10), ACEs were positively associated with use of alcohol at the time of interview OR=1.3 (95% CI: 1.1, 1.5). Studies that assessed the association between ACEs and nicotine used thresholds between 15-17 to define early initiation and reported a range of effect sizes (OR) from 1.6 (95% CI: 1.2, 2.2) after exposure to more than one ACE to 5.2 (95% CI: 2.9, 9.3) after exposure to more than two ACEs. Exposure to two or more ACEs was associated with initiating vaping before age 11 (OR=3.4 (95% CI: 2.2, 5.4). While not rising to statistical significance (p<0.05), findings from the second study suggest there is a small inverse relationship between maternal ACEs and offspring age of alcohol initiation among the full sample. However, among offspring exposed to >2 ACEs themselves, 2 maternal ACEs are associated with =-1.4 (95% CI: -2.7, -0.1) and >2 maternal ACEs are associated with =-2.1 (95% CI: -3.8, -0.5) earlier age of alcohol initiation. These findings suggest that offspring exposed to high levels of intergenerational ACE exposure are at greatest risk for early alcohol initiation. Findings from the third study suggest that maternal ACEs are associated with offspring internalizing and externalizing behavior in a dose-dependent manner, independent of offspring ACE exposure. Specifically, 1, 2, and >2 maternal ACEs were independently associated with a 1.8 (95% CI: 0.9, 2.8), 2.1 (95% CI: 0.7, 3.4), and 2.7 (95% CI: 1.0, 4.4) increase in internalizing score and a 1.8 (95% CI: 0.8, 2.7), 3.1 (95% CI: 1.7, 4.4), and 3.3 (95% CI: 1.4, 5.1) increase in externalizing score, respectively. Taken together, findings from this investigation suggest that universal ACE screening in pediatric settings, particularly prior to onset of puberty, may identify youth for service provision prior to substance initiation and that maternal ACEs should be screened for and considered in addition to offspring ACE exposure to inform interventions related to adolescent substance use and internalizing and externalizing behavior. To that end, the prenatal period may be an opportune time for maternal ACE screening. Conclusions from these investigations may apply to the impact of maternal ACEs on other relevant offspring outcomes across the life course. Future directions for research, including assessment of relevant biological and psychosocial mechanisms, and potential moderators of identified associations are discussed.
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    WOMEN’S AUTONOMY AND REPRODUCTIVE AND PERINATAL HEALTH OUTCOMES IN AFGHANISTAN
    (2024) Ibrahimi, Sahra; Thoma, Marie; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Studies show that women’s autonomy (WA)--as measured by household decision making, healthcare decision making, and permission to go out--facilitates access to resources, including education, employment, and healthcare resources. In return, these resources determine maternal and child health. Prior studies, conducted in countries other than Afghanistan, have resulted in inconsistent findings because the degree and direction of the association between WA and health outcomes differ among countries based on their laws and cultural context. There is no research examining the impact of WA on reproductive and perinatal health outcomes in Afghanistan. Conducting this research in Afghanistan is critical given the country’s unique political and socio-cultural environment that shape its population health. For instance, less than one in two of Afghan women make decisions about their healthcare, while 53% of them have experienced physical domestic violence. The 2021 ruling of the country by the Taliban has exacerbated the violation of women’s rights in Afghanistan, making the examination of the impact of WA on reproductive health outcomes even more pertinent. My dissertation addresses these gaps in the literature by examining the association between women’s autonomy and 1. experience of domestic violence types (physical, sextual, and emotional), 2. unintended pregnancy, and 3. pregnancy loss. I also assess the moderating effect of education on the association of WA and domestic violence, and the mediating effect of domestic violence on the association of WA and unintended pregnancy and pregnancy loss. I used data from 19,098 married women aged 15-49, who completed the 2015 Afghanistan Demographic and Health Survey- the first and only national survey administered in the country. WA was measured across 5 domains (healthcare, visiting family, household purchases, spending, and contraceptive use). Adjusted odds ratios and 95% confidence intervals for the association between WA and the outcomes of interest were estimated using multiple logistic regression and adjusted for relevant confounders including age, ethnicity, education, wealth, residency, and parity. Additionally, to assess moderation and mediation, interaction terms and casual mediation models were used for each respective analysis. I found that about one in two Afghan women did not have autonomy in making decisions and experienced domestic violence, and approximately one in ten women experienced unintended pregnancy and pregnancy loss. In Aim 1, in the adjusted Model 2 (adjusting for confounders), women’s autonomy in healthcare decisions (Adjusted odds ratio [AOR]=0.70, CI: 0.60-0.81), spending (AOR=0.58, CI: 0.51-0.66), visiting families (AOR=0.69, CI: 0.60-0.80), household purchases (AOR=0.59, CI: 0.52-0.68), and not using contraception (AOR=0.66, CI: 0.46-0.93) were significantly associated with decreased experience of physical violence. In addition, women’s autonomy in healthcare decisions (AOR = 0.51, 95% CI: 0.39-0.65), spending (AOR=0.62, CI: 0.48-0.80), and household purchases (AOR=0.56, CI: 0.43-0.72) were significantly associated with decreased experience of sexual violence. Lastly, women’s autonomy in healthcare (AOR=0.82, CI: 0.72-0.94), spending (AOR=0.61, CI: 0.53-0.71), visiting families (AOR=0.79, CI: 0.70-0.88), and not using contraception (AOR=0.58, CI: 0.42-0.80) were significantly associated with decreased experience of emotional violence. We also found a greater protective effect of WA in visiting family among women with some education (vs. no education) across each domestic violence outcome. In Aim 2, Model 2, women’s autonomy in healthcare decisions (AOR=0.87, CI: 0.77 - 0.97) and spending (AOR=0.86, CI: 0.76 - 0.97) were significantly associated with decreased experience of unintended pregnancy. However, women’s autonomy in visiting families (AOR=1.15, CI: 1.02 - 1.29) was associated with slightly increased experience of unintended pregnancy. This association was partially mediated by physical and sexual domestic violence (21% of total effect mediated by domestic violence) in that the reduction of violence with WA attenuated the effect of WA on unintended pregnancy. Lastly, in Aim 3, Model 2, women’s autonomy in healthcare decisions (AOR=0.86, CI: 0.78 - 0.95), household purchases (AOR=0.87, CI: 0.79 - 0.97), and visiting families (AOR=0.90, CI: 0.82 - 1.00), were significantly associated with decreased experience of pregnancy loss. Some of the protective effects of autonomy in healthcare (18%) and household purchase (15%) on pregnancy loss were mediated through reduced experience of domestic violence during pregnancy. Beyond filling the gap in the literature, this study provides evidence and brings awareness (about the impact of the lack of women’s autonomy on adverse health outcomes) that is needed to urge policymakers and program implementers in targeting and improving women’s autonomy and health outcomes in Afghanistan. The findings of this study can also be translated into Dari and Pashto and be shared with the general public in Afghanistan. Interventions that may improve women’s autonomy and health outcomes in Afghanistan, such as establishing laws about women’s rights, granting access to education, awareness campaigns, microfinancing, and community-based distribution programs, could foster gender equity and improve maternal and child health – moving to more sustainable development, consistent with Sustainable Development Goal (SDG) 3 and 5.
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    EXAMINING THE ASSOCIATION BETWEEN INTERPREGNANCY INTERVAL AND MATERNAL HEALTH IN THE POSTPARTUM PERIOD
    (2023) Barber, Gabriela A; Thoma, Marie E; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Interpregnancy interval (IPI) is defined as the period of time between a previous birth and a subsequent conception, usually measured in months. While recommendations issued by the World Health Organization and the American College of Obstetricians and Gynecologists provide guidance for ideal birth spacing, many births occur after non-optimal IPIs – either too short (<18 months) or too long (60+ months). These recommendations were motivated by the body of research on a host of adverse infant and maternal health outcomes associated with non-optimal IPIs. To date, the literature has focused heavily on the association between IPI and adverse infant health outcomes, with limited attention in comparison being given to IPI and maternal health. Within the research on IPI and maternal health, there is a narrow focus on physical health outcomes related to pregnancy/delivery complications, with few studies looking at health outcomes in the postpartum and beyond. In order to fill this gap, this research investigated the association between IPI and several postpartum maternal health outcomes/indicators, including 1) postpartum depression (PPD), 2) attendance at a postpartum checkup, and 3) postpartum contraceptive use (any and type). One of the perennial difficulties in studying IPI is parsing out whether IPI has an independent association with a health outcome or behavior or is exerting its effects through pregnancy intention, therefore, for each aim, pregnancy intention was tested as a moderator. For each aim, unique cut-offs for IPI were determined after examination of the association between more detailed IPI categories and the outcome of interest. Categories were collapsed into broader IPI classifications when the associations were similar in order to maximize precision of the estimates and in order to allow us to characterize the most clinically relevant exposure for specific health outcomes. In fully adjusted models, individuals who had IPIs less than 18 months were significantly more likely to experience elevated PPD symptoms (aOR: 1.19, 95% CI: 1.02 – 1.39, p=0.024) when compared to individuals with long IPIs, and individuals who had IPIs less than 12 months were significantly less likely to attend their postpartum checkup (aOR: 0.78, 95% CI: 0.66 – 0.93, p=0.006) when compared to those with long IPIs. Pregnancy intention was not found to significantly moderate either of these associations. For the third aim, pregnancy intention was found to moderate the association between IPI and any use of postpartum contraception. Stratified analyses show that it is among unintended pregnancies that there is an association between short IPI and increased use of any contraception in the postpartum. Among unintended pregnancies, those with IPIs less than 6 months (aOR: 2.31, 95% CI: 1.37 – 3.90, p=0.002) and those with IPIs of 6-11 months (aOR: 2.15, 95% CI: 1.48 – 3.10, p=0.001) were more likely to be using any contraception in the postpartum than those with long IPIs, and the magnitude of this association exceeded that of other IPI intervals and pregnancy intention categories. Among those who were using contraception in the postpartum, individuals with IPIs less than 6 months were more likely to be using highly-effective methods (aOR: 1.59, 95% CI: 1.22 – 2.10, p=0.001) than least-effective methods of contraception. Pregnancy intention did not significantly moderate the association between IPI and type of contraception. Future research should continue to explore the association between IPI and a broader range of maternal health outcomes and work to identify the mechanisms through which IPI may be impacting these outcomes. Recent changes in reproductive policies in the U.S. may also soon change the proportion of individuals who experience short IPIs, therefore making it even more important to understand how this shift may impact a broad range of maternal health behaviors and outcomes. This research highlights how an increase in births occurring after a short IPI would likely increase rates of PPD and increase demand for certain family planning services.
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    THE LONGER-TERM IMPACT OF PERCEIVED DISCRIMINATION ON COUPLE RELATIONSHIP FUNCTIONING: EXAMINING PSYCHOLOGICAL AND PHYSIOLOGICAL PATHWAYS AMONG MIDDLE-AGED AND OLDER-AGED ADULTS IN THE UNITED STATES
    (2023) Du, Jingshuai; Quinn, Sandra SQ; Mittal, Mona MM; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    The current study aimed to investigate the longer-term impact of everyday discrimination and major lifetime discrimination at Time 1 (T1; 2008 and 2010) on couple relationship functioning at Time 3 (T3; 2016 and 2018) across 8 years. It also aimed to explore if psychological (measured by depressive symptoms) and physiological stress responses (measured by allostatic load) at Time 2 (T2; 2012 and 2014) mediated the longitudinal association between discrimination and couple relationship functioning among middle-aged and older-aged adults in the United States (U.S.). To answer the study aims, I conducted a longitudinal mediation path analysis (N = 2,344) in Mplus Version 8 using data from the Health and Retirement Study, an ongoing national survey of the health and aging experience of U.S. adults aged 51 and older residing in the community. The primary longitudinal mediation model with control variables demonstrated good model fit (χ2[4] = 21.78, p < 0.01, CFI = 0.99, RMSEA = 0.04, SRMR = 0.01). The analysis results suggested that depressive symptoms at T2 significantly mediated the longitudinal association between the two types of discrimination and the two types of couple relationships spanning 8 years while controlling for race, age, gender, education, number of reasons for everyday discrimination and T1 assessments of couple support and couple strain. However, allostatic load was not found to be a significant mediator between the two types of discrimination and the two aspects of couple relationship functioning (couple support and couple strain). The direct relationship between discrimination (everyday and major lifetime discrimination) and couple relationship functioning (couple strain and couple support) was not significant either. The results from the multi-group analysis suggested that several structural paths differed significantly across gender, age groups, and number of reasons for everyday discrimination, but none of the paths differed significantly based on race. Overall, the current study did not find evidence supporting the pathway from perceived discrimination to couple relationship functioning through allostatic load. It provided evidence supporting depressive symptoms as a mediating mechanism between perceived discrimination and couple relationship functioning. Future work should develop innovative methods for assessing and measuring allostatic load to test its possible mediation role between perceived discrimination and couple relationship functioning. Moreover, effective and culturally-responsive interventions and programs are needed to decrease all types of discrimination and depression in order to improve couple relationship functioning among middled-aged and older-aged adults in the U.S.
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    Influence of Latinx Fathers' Behaviors, Cognitions, Affect, and Family Congruence on Youth Energy Balance-Related Health Outcomes
    (2022) Rodriguez, Matthew Rene; Roy, Kevin; Hurtado Choque, Ghaffar Ali; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    For decades, researchers have studied and theorized about the ways fathers interact with children and other members of the family. While this research provides important evidence, few father involvement studies have included Latinx fathers. Numerous father involvement conceptual frameworks have helped us understand the ways fathers interact with their families. Much of this research has focused on fathers' behaviors, but research suggests other domains need more investigation, such as fathers' cognitions and affect. Understanding these additional domains of father involvement can provide important evidence for understanding the ways fathers influence the health of children. Fathers influence the health of their children within different cultural and socio-political contexts. When considering Latinx father involvement within a social determinants of health approach, research has encouraged focusing on upstream factors that can contribute to the health of Latinx families. Addressing these upstream factors can shape the health and wellbeing of children. Currently, Latinx youth suffer disproportionately from obesity compared to all other racial and ethnic groups in the U.S. Through investigating Latinx father involvement, I fill an important gap by researching the extent to which Latinx fathers' affect, behaviors, and cognitions shape youth health outcomes. I also investigate theorized moderators that may influence the relationship between fathers' involvement and youth health outcomes. Using a cross sectional study design with a community-based sample of Latinx fathers and youth (ages 10-14) (n=193), I use latent moderation structural analyses to test the theorized causal mechanisms.
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    A Qualitative Examination of the Barriers and Facilitators of Pre-Exposure Prophylaxis (PrEP) Uptake Among Heterosexual HIV Serodiscordant Couples
    (2022) Mathews, Ronneal; Mittal, Mona; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    It is estimated that there are 140,000 heterosexual serodiscordant couples in the United States. Given the considerable number of these couples and the high risk of HIV acquisition among non-infected partners, it is important to focus prevention methods on programs and interventions that target transmission of HIV infection among serodiscordant heterosexual couples. Currently, we understand little about factors that influence these couples to use pre-exposure prophylaxis (PrEP). According to the CDC, this population is one of the highest risk groups, therefore, understanding the factors that influence them to use PrEP as a strategy in their HIV prevention regimen is an important step in preventing new HIV cases among this population. This study was a qualitative analysis that explored potential motivators and inhibitors for PrEP among heterosexual HIV serodiscordant couples. Secondary data from 26 qualitative interviews of HIV serodiscordant couples (N = 52 individuals) was examined to determine the factors that influenced the decision to use PrEP. Overall, there were five overarching themes from the Health Belief Model that manifested in all participant interviews. Perceived threat, perceived barriers (concerns about side effects, fear/anxiety about taking medication, indifference about HIV transmission), perceived benefits, cues to action (partner protection, PrEP use as condom replacement, PrEP use due to concerns about condom efficacy), and relational efficacy emerged as the most salient themes that determined whether couples chose to use PrEP as an HIV prevention method. Two constructs from the Theory of Gender and Power, sexual division of power and cathexis also emerged as relevant factors that influenced the decision to use PrEP in these couples. Findings from this study indicate that practitioners need to consider the motivators and barriers to PrEP uptake, and critically examine how power dynamics impact the decision to use PrEP. There is a need for the development of couples-based interventions to encourage PrEP uptake and adherence in mixed status couples.
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    Evaluating immigrant-specific adverse childhood experiences as a social determinant of health among Latino immigrant families
    (2022) Conway, C. Andrew; Lew, Amy; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Research consistently demonstrates the critical role of Adverse Childhood Experiences (ACEs), traditionally defined as exposure to abuse, neglect, and household risk factors, in shaping overall health and well-being throughout life and even across generations. However, our current conceptualization and measurement of ACEs are based on items initially examined in a primarily white, middle-class, highly educated sample. This strategy may provide a limited understanding of childhood adversity within marginalized groups. This study aimed to examine the relationship between ACEs (both traditionally studied ACEs and immigrant-specific ACEs) and the psychological well-being of Latino immigrant adolescents. The relationship between parental experiences of ACEs, child ACEs, and child psychological well-being was also explored. Data comes from a community sample of 338 Latino immigrant adolescents. These youth completed an 11-item measure of traditional ACEs (ACE-T), a novel 13-item measure of immigrant-specific ACEs (ACE-I), the Strengths and Difficulties Questionnaire, and health risk behavior items as part of the intake process for a positive youth development program. Data on parent ACEs was available for a subsample (n¬ = 112). Structural equation modeling was used to examine the relationship between the ACEs measures and the psychological and health risk outcomes. Immigrant youth, on average, reported more adversities on the ACE-I measure than the ACE-T measure (3.6 vs. 1.6). Both ACE-T and ACE-I scores were positively related to increased emotional issues (standardized coefficients were .24 and .25, respectively). Only ACE-T scores were related to increased conduct problems and peer relationship problems. There was no relationship between adolescents' ACE-T or ACE-I scores with prosocial or health risk behaviors. The parent's ACE-T scores were positively related to the child's ACE-T scores (b = .18). These findings suggest that essential early adverse experiences for immigrants, which have not been considered, impact adolescents' psychological well-being. Broadening our conceptualization and measurement of ACEs among immigrant populations could provide valuable insight into social determinants of health and avenues for intervention for immigrant adolescents and families.
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    INSTITUTIONAL RACISM AND MATERNAL AND CHILD HEALTH: EXPLORING THE RELATIONSHIP BETWEEN CORRECTIONAL CONTROL, MATERNAL MORBIDITY, AND PRETERM BIRTH
    (2021) Ramsey, Lauren Meta; Moser Jones, Marian; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Racism permeates all U.S. institutions. The criminal justice system has been identified as a clear form of structural racism. Numerous studies have documented disproportionate criminal justice contact among Black people. Several researchers have used the Black/White differences in incarceration as an indicator of racism. However, there are 4.5 million people under community supervision, in addition to the 2.3 million people incarcerated in the U.S. Despite this large number of the population being under this type of correctional supervision, probation and parole does not receive as much attention in studies of institutional racism and health. Probation and parole are important to consider in any investigation of criminal justice system involvement because they are major drivers of mass incarceration in the United States. Incarceration, parole and probation can have negative effects on individuals, families and communities, with Black people disproportionately impacted by these negative outcomes. This study utilized the indicator of Black/White differences in Correctional Control (defined as populations who are on probation, paroled and incarcerated in jail and state prison) as a proxy for institutional racism on overall population health. This dissertation utilized Pregnancy Risk Assessment Monitoring System (PRAMS), and Bureau of Justice Statistics data to investigate the relationship between institutional racism (i.e. Black/white differences in state level Correctional control) on disparities in rates of preterm birth, postpartum depression and pregnancy hypertension among Black and White women.
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    FEMALE GENITAL CUTTING IN NIGERIA: AN EXPLORATION OF NATIONAL-LEVEL TRENDS AND ITS ASSOCIATIONS WITH SEXUAL AND REPRODUCTIVE HEALTH
    (2021) Drew, Laura Briggs; Thoma, Marie E; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    20% of women and girls in Nigeria have undergone female genital cutting (FGC). Although FGC may have cultural and religious importance, it is a violation of human rights and is associated with long-term impacts on women’s health. FGC is practiced to ensure marriage eligibility and attenuate sexual desires, but intercourse can be painful for women with FGC, and while there appears to be a relationship between FGC and STIs and infertility, these pathways are not clear. Therefore, this dissertation utilized Nigeria Demographic and Health Survey (NDHS) data to accomplish the following three aims: 1) Examine trends in women’s attitudes and beliefs toward FGC from 2003-2018 in Nigeria, including after criminalization of FGC in 2015, and by region; 2) Assess the association between FGC and sexual behaviors among couples; and 3) Examine the relationship between FGC and delays in pregnancy via time-to-pregnancy (TTP). The first study found women’s attitudes and religious beliefs toward FGC have changed in Nigeria, with support and religious beliefs toward FGC decreasing in the South, but increasing in the North. These variations may reflect concerted efforts to address FGC through state-level policies and anti-FGC programs in the southern regions where it is more commonly practiced, while the northern regions have experienced ongoing conflicts. The second study found women with FGC are less likely to have been recently sexually active, more likely to be sexually active before age 18, their partners are more likely to have had extramarital sexual partners in the past year, and the magnitude of these associations is greater for women with more severe forms of FGC. The third study found more severe forms of FGC may lead to longer TTP among nulliparous women, but the relationship between FGC and increased TTP was not evident among parous women. However, these associations may be complicated by differences in fertility preferences and sexual behaviors. As we move forward in efforts to prioritize the sexual and reproductive health and rights of women and girls across the globe, examining the impact that cultural practices, like FGC, can have on health behaviors is a critical area of research.
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    Examining Maternal Experiences of Food Insecurity on Birth and Early Childhood Outcomes
    (2020) De Silva, Dane André; Thoma, Marie E; Family Studies; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Food insecurity, or the inadequate access to nutritionally-acceptable food, has been increasingly recognized as a distal determinant of poor health outcomes. While 11.1% of U.S. households suffer from food insecurity, specific populations are disproportionately affected, including pregnant women and single mothers. From a life course perspective, growth trajectories may be influenced by both prenatal exposures and postpartum practices, such as breastfeeding. Since food insecurity is associated with stress and poor nutrition, when occurring during critical periods of development, the fetus may be programmed to have poor future health. Other research on developmental origins have identified patterns that exhibit sex differences, particularly around growth. Therefore, this investigation sought to examine maternal food insecurity on: (i) low birthweight and sex-specific differences; (ii) breastfeeding initiation and exclusive breastfeeding duration; and (iii) obesity at age two and sex-specific differences. In Aim 1, mothers experiencing prenatal food insecurity had a higher odds of delivering a low birthweight infant, though much of the association was explained by sociodemographic factors after adjustment (OR 1.10 [95%CI 0.98, 1.25]), with female infants showing OR 1.21 (95%CI 1.02, 1.43). For Aim 2, food insecurity did not appear to deter women from initiating breastfeeding (OR 1.41 [95%CI 0.58, 3.47]), and minimal differences in exclusive breastfeeding duration between food insecure and food secure women were found (TR 0.89 [95%CI 0.57, 1.39]). Finally, Aim 3 revealed that sociodemographic factors explained much of the association between maternal food insecurity and childhood obesity at 2 years (OR 1.15 [95%CI 0.75, 1.75]), though male offspring showed a stronger magnitude (OR 1.54 [95%CI 0.86, 2.74]). Maternal food insecurity is a multi-faceted exposure that is related to other covariates, which may interact in multiple ways to influence health outcomes through both biologic and behavioral pathways. This preliminary investigation highlights the importance of exploring exposures occurring during critical periods, including food insecurity, on birth and childhood outcomes, and how it may affect the later health of offspring differently by sex. Additional longitudinal data with accurate measures of food insecurity are needed to fully ascertain how it affects the health of mothers and children, and to identify possible mediating pathways.