Gemstone Team Research
Permanent URI for this communityhttp://hdl.handle.net/1903/9069
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Item Developing A Broadly Protective MRNA Influenza Vaccine: A Review(2022) Acquah, Wellington; Amini, Cameron; Buddula, Saharsh; Chen, Michelle; Chintala, Navya; Dang, Quinn; Ferziger, Noa; Hollis, Grace; Jameison, Devin; Jayaram, Jyostna; Manus, Joseph Anthony; Rosenberg, Jacob; Zhiteneva, Julia; Yarwood, StephanieCurrent influenza vaccines are limited in their efficacy due to antigenic drift of the hemagglutinin target; advances in mRNA vaccines in response to the COVID-19 pandemic may provide a new direction for influenza vaccine development. Existing literature shows that mRNA vaccines have higher efficacy in preventing illness, hospitalizations, and death. We evaluated eleven influenza A viral proteins as potential targets for an mRNA vaccine under the following criteria: degree of conservation, ability to elicit a robust immune response, and ability to prevent illness and death. We recommend future researchers direct their efforts towards developing an annually administered tri-sequence mRNA vaccine targeting hemagglutinin head (HA1), the matrix 2 ectodomain (M2e), and nucleoprotein (NP). Development of a highly effective influenza mRNA vaccine would be significant for prevention of disease burden worldwide.