Theses and Dissertations from UMD
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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM
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Item THE LONG-TERM IMPACT OF PREVIOUS COCAINE SELF-ADMINISTRATION ON DECISION-MAKING AND STRIATAL CIRCUITRY(2017) Burton, Amanda Claire; Roesch, Matthew R; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Current theories of addiction suggest that impaired decision-making observed in individuals that chronically abuse drugs reflects a decrease in goal-directed behaviors and an increase in habitual behaviors governed by neural representations of response-outcome and stimulus-response associations, respectively. The striatum is a critical input component to the basal ganglia, which is a complex set of subcortical brain structures involved in the selection and execution of actions. Striatal sub-regions are some of the first brain regions to be affected by drugs of abuse, yet we still do not fully understand how decision-making and neural correlates in these regions are affected by drug exposure or disruptions within the circuit. My project was designed to study behavioral and neural changes in the striatum after previous cocaine self-administration or pharmacological lesion while rats perform a complex decision-making task. I therefore implemented a cocaine self-administration or pharmacological lesion protocol and recorded from single neurons in striatal sub-regions, specifically the nucleus accumbens core (NAc) and dorsal lateral striatum (DLS), during performance of an odor-guided decision-making task in which reward contingencies often changed. This task independently manipulated value of expected reward by changing the delay to or size of reward across a series of blocks of trials. I found that previous cocaine self-administration made rats more impulsive, biasing choice behavior toward more immediate reward. After cocaine exposure, there were fewer task-responsive neurons in the NAc and in those that remained we observed diminished directional and value encoding compared to controls. Surprisingly, in the DLS I found evidence of increased response-outcome associations and no evidence of enhanced stimulus-response associations after cocaine exposure. After disrupting communication between the NAc and DLS, I found evidence of enhanced stimulus-response associations in the DLS during task performance. This suggests that cocaine exposure impacts decision-making and neural activity in the striatum that manifests in more complex ways than simply disrupting striatal circuitry as current theories of addiction suggest.Item Response inhibition and the cortico-striatal circuit(2015) Bryden, Daniel William; Roesch, Matthew R; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)The ability to flexibly control or inhibit unwanted actions is critical for everyday behavior. Lack of this capacity is characteristic of numerous psychiatric diseases including attention deficit hyperactivity disorder (ADHD). My project is designed to study the neural underpinnings of response inhibition and to what extent these mechanisms are disrupted in animals with impaired impulse control. I therefore recorded single neurons from dorsal striatum, orbitofrontal cortex, and medial prefrontal cortex from rats performing a novel rodent variant of the classic "stop signal" task used in clinical settings. This task asks motivated rats to repeatedly produce simple actions to obtain rewards while needing to semi-occasionally inhibit an already initiated response. To take this a step further, I compared normal rats to rats prenatally exposed to nicotine in order to better understand the mechanism underlying inhibitory control. Rats exposed to nicotine before birth show abnormal attention, poor inhibitory control, and brain deficits consistent with impairments seen in humans prenatally exposed to nicotine and those with ADHD. I found that dorsal striatum neurons tend to encode the direction of a response and the motor refinement necessary to guide behaviors within the task rather than playing a causal role in response inhibition. However the orbitofrontal cortex, a direct afferent of dorsal striatum, possesses the capacity to inform the striatum of the correct action during response inhibition within the critical time window required to flexibly alter an initiated movement. On the other hand, medial prefrontal cortex functions as a conflict “monitor” to broadly increase preparedness for flexible response inhibition by aggregating current and past conflict history. Lastly, rat pups exposed to nicotine during gestation exhibit faster movement speeds and reduced capacity for inhibitory behavior. Physiologically, prenatal nicotine exposure manifests in a hypoactive prefrontal cortex, diminished encoding of task parameters, and reduced capacity to maintain conflict information.Item Reward modulation of inhibitory control during adolescence: An age related comparison of behavior and neural function(2010) Hardin, Michael George; Fox, Nathan A; Human Development; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)The developmental period of adolescence is distinguished by a transition from the dependent, family-oriented state of childhood to the autonomous, peer-oriented state of adulthood. Related to this transition is a distinct behavioral profile that includes high rates of exploration, novelty-seeking, and sensation-seeking. While this adolescent behavioral profile generally aids in the transition to autonomy, it comes at a cost and is often related to excessive risk-taking behavior. Current models attribute the adolescent behavioral profile to a developmental discordance between highly sensitive reward-related processes and immature inhibitory control processes. Specifically, reward-related processes appear to develop in a curvilinear manner characterized by a heightened sensitivity to reward that peaks during adolescence. On the other hand, inhibitory processes show a protracted linear developmental trajectory that begins in childhood and continues gradually throughout adolescence. Thus, the unique developmental trajectories of these two sets of processes leave the adolescent with highly sensitive, reward-driven processes that can only be moderately regulated by gradually developing inhibitory processes. Despite the usefulness of these models of adolescent behavior, they remain incompletely supported by data, as few studies specifically examine the interaction between reward-related and inhibitory processing. The current study addresses this particular gap in the adolescent neural development literature by administering a reward-modified inhibitory control task to children, adolescents, and young adults during functional neuroimaging. Three key findings emerged from the current study. First, adolescents showed greater inhibition-related neural responses than both adults and children when potential monetary reward was available. Second, adolescents reliably showed greater striatal recruitment with reward than both adults and children. These differences in striatal response occurred as all three age groups showed significant reward-related behavioral improvements. Third, when reward was not present, adolescents and children showed deficient inhibitory behavior relative to adults. Findings from this study support models proposing interactive relationships between heightened adolescent sensitivity to reward and protracted development of inhibitory control. Additionally, the current findings expand these models by suggesting heightened adolescent sensitivity to reward may facilitate developmentally inefficient inhibitory control processes in a bottom-up manner.