Organophosphorous pesticide breakdown products in house dust and children’s urine.

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dc.contributor.authorQuiros-Alcala, Lesliam
dc.contributor.authorBradman, Asa
dc.contributor.authorSmith, Kimberly
dc.contributor.authorWeerasekera, Gayanga
dc.contributor.authorOdetokun, Martins
dc.contributor.authorBarr, Dana B.
dc.contributor.authorNishioka, M
dc.contributor.authorCastorina, R
dc.contributor.authorHubbard, AE
dc.contributor.authorNicas, M
dc.contributor.authorHammond, SK
dc.contributor.authorMcKone, TE
dc.contributor.authorEskenazi, B
dc.date.accessioned2016-11-11T19:05:20Z
dc.date.available2016-11-11T19:05:20Z
dc.date.issued2012
dc.description.abstractHuman exposure to preformed dialkylphosphates (DAPs) in food or the environment may affect the reliability of DAP urinary metabolites as biomarkers of organophosphate (OP) pesticide exposure. We conducted a study to investigate the presence of DAPs in indoor residential environments and their association with children’s urinary DAP levels. We collected dust samples from homes in farmworker and urban communities (40 homes total, n=79 samples) and up to two urine samples from resident children ages 3-6 years. We measured six DAPs in all samples and eight DAP-devolving OP pesticides in a subset of dust samples (n=54). DAPs were detected in dust with diethylphosphate (DEP) being the most frequently detected (>=60%); detection frequencies for other DAPs were <=50%. DEP dust concentrations did not significantly differ between communities, nor were concentrations significantly correlated with concentrations of chlorpyrifos and diazinon, the most frequently detected diethyl-OP pesticides (Spearman r=0.41 to 0.38, P>0.05). Detection of DEP, chlorpyrifos, or diazinon, was not associated with DEP and/or DEPþdiethylthiophosphate detection in urine (Kappa coefficients=-0.33 to 0.16). Finally, estimated nondietary ingestion intake from DEP in dust was found to be <=5% of the dose calculated from DEP levels in urine, suggesting that ingestion of dust is not a significant source of DAPs in urine if they are excreted unchanged.en_US
dc.description.sponsorshipThis work was supported by EPA (RD 83171001) and NIEHS (PO1 ES009605). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the EPA, NIEHS, or other funders. Additional support was provided by an EPA STAR Doctoral Fellowship (F5D30812), the University of California Institute for Mexico and the United States (UC MEXUS), and the Center for Latino Policy Research at the University of California at Berkeley.en_US
dc.identifierhttps://doi.org/10.13016/M2VZ36
dc.identifier.citationQuiros-Alcala L, Bradman A, Smith K, Weerasekera G, Odetokun M, Barr DB,Nishioka M, Castorina R, Hubbard AE, Nicas M, Hammond SK, McKone TE, and Eskenazi B. Organophosphorous pesticide breakdown products in house dust and children's urine. Journal of Exposure science & Environmental Epidemiology. 2012;22(6):559-68.en_US
dc.identifier.urihttp://hdl.handle.net/1903/18878
dc.relation.isAvailableAtSchool of Public Health
dc.relation.isAvailableAtMaryland Institute of Applied Environmental Health
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectbiomarkersen_US
dc.subjectdialkylphosphates
dc.subjectdust
dc.subjectmetabolites
dc.subjectorganophosphates
dc.subjecturine
dc.titleOrganophosphorous pesticide breakdown products in house dust and children’s urine.en_US
dc.typeOtheren_US

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