NON-INVASIVE IMAGING TECHNIQUES AS A QUANTITATIVE ANALYSIS OF SKIN DAMAGE DUE TO IONIZING RADIATION

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dc.contributor.advisorTao, Yangen_US
dc.contributor.authorVogel, Abby Jeanneen_US
dc.contributor.departmentBiological Resources Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2004-07-16T05:16:11Z
dc.date.available2004-07-16T05:16:11Z
dc.date.issued2004-05-06en_US
dc.description.abstractThis study tested the ability of two non-invasive techniques, thermography and near-infrared multi-spectral imaging, to quantitatively assess the response of mouse skin to a single dose of X-ray irradiation. Thermal images from an 8-12 micron thermal camera were recorded after a cold stimulation to see the thermal recovery of the skin. The irradiated areas showed a significantly faster thermal recovery than the non-irradiated areas two weeks after radiation (p < 0.05). The NIR multi-spectral imager obtained images at six specially selected wavelengths between 700 and 1000 nm. Two-layer model-based diffuse reflectance spectroscopy monitored changes in blood oxygen saturation and blood volume. Blood oxygen fractions were significantly lower after radiation (p < 0.05). Blood volume changed in six of seven irradiated mice one week after radiation. The non-invasive imaging techniques were successful in quantitatively analyzing the response of the skin to a single dose of irradiation.en_US
dc.format.extent3959071 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/1667
dc.language.isoen_US
dc.subject.pqcontrolledEngineering, Biomedicalen_US
dc.subject.pquncontrolledThermographyen_US
dc.subject.pquncontrolledMulti-Spectral Imagingen_US
dc.subject.pquncontrolledIonizing Radiationen_US
dc.subject.pquncontrolledNon-Invasiveen_US
dc.subject.pquncontrolledLaser Doppler Imagingen_US
dc.titleNON-INVASIVE IMAGING TECHNIQUES AS A QUANTITATIVE ANALYSIS OF SKIN DAMAGE DUE TO IONIZING RADIATIONen_US
dc.typeThesisen_US

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