Drug Delivery through the Blood-Brain Barrier through Use of Vascular Cell Adhesion Molecule 1- Targeted Nanoparticles

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dc.contributor.advisorAranda-Espinoza, Jose Helim
dc.contributor.authorAdnan, Sakib
dc.contributor.authorBorsellino, Regina
dc.contributor.authorHe, Alice
dc.contributor.authorMukherjee, Somdutta
dc.contributor.authorPeng, Victor
dc.contributor.authorPotti, Karthya
dc.contributor.authorShih, Kelly
dc.contributor.authorVaitkus, Janina
dc.contributor.authorWang, Victor
dc.contributor.authorWoo, Rani
dc.contributor.authorZhang, Robert
dc.date.accessioned2013-05-01T18:58:52Z
dc.date.available2013-05-01T18:58:52Z
dc.date.issued2013
dc.description.abstractThe blood brain barrier (BBB) is a semi-permeable membrane separating the brain from the bloodstream, preventing many drugs that treat neurological diseases, such as Alzheimer’s and Parkinson’s, from reaching the brain. Our project aimed to create a novel drug delivery system targeting the brain during neural inflammation. We developed a cationic solid lipid nanoparticle (CSLN) complex composed of cationic nanoparticles, biotin, streptavidin, and anti-vascular cell adhesion molecule-1 (anti- VCAM-1) antibodies. The anti-VCAM-1 antibody is used to target VCAM-1, a cell adhesion protein found on the BBB endothelium. VCAM-1 expression is elevated in the presence of inflammatory molecules, such as tumor necrosis factor-alpha (TNF- α). Through the use of a simple BBB model, results showed that our novel drug delivery system experienced some level of success in targeting the brain inflammation due to increasing TNF-α concentrations. This is promising for drug delivery research and provides support for VCAM-1 targeting using more robust and complex BBB models.en_US
dc.identifier.urihttp://hdl.handle.net/1903/13876
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team B3en_US
dc.subjectblood brain-barrieren_US
dc.subjectvascular cellen_US
dc.subjectnanoparticlesen_US
dc.titleDrug Delivery through the Blood-Brain Barrier through Use of Vascular Cell Adhesion Molecule 1- Targeted Nanoparticlesen_US
dc.typethesisen_US

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