Drug Delivery through the Blood-Brain Barrier through Use of Vascular Cell Adhesion Molecule 1- Targeted Nanoparticles
dc.contributor.advisor | Aranda-Espinoza, Jose Helim | |
dc.contributor.author | Adnan, Sakib | |
dc.contributor.author | Borsellino, Regina | |
dc.contributor.author | He, Alice | |
dc.contributor.author | Mukherjee, Somdutta | |
dc.contributor.author | Peng, Victor | |
dc.contributor.author | Potti, Karthya | |
dc.contributor.author | Shih, Kelly | |
dc.contributor.author | Vaitkus, Janina | |
dc.contributor.author | Wang, Victor | |
dc.contributor.author | Woo, Rani | |
dc.contributor.author | Zhang, Robert | |
dc.date.accessioned | 2013-05-01T18:58:52Z | |
dc.date.available | 2013-05-01T18:58:52Z | |
dc.date.issued | 2013 | |
dc.description.abstract | The blood brain barrier (BBB) is a semi-permeable membrane separating the brain from the bloodstream, preventing many drugs that treat neurological diseases, such as Alzheimer’s and Parkinson’s, from reaching the brain. Our project aimed to create a novel drug delivery system targeting the brain during neural inflammation. We developed a cationic solid lipid nanoparticle (CSLN) complex composed of cationic nanoparticles, biotin, streptavidin, and anti-vascular cell adhesion molecule-1 (anti- VCAM-1) antibodies. The anti-VCAM-1 antibody is used to target VCAM-1, a cell adhesion protein found on the BBB endothelium. VCAM-1 expression is elevated in the presence of inflammatory molecules, such as tumor necrosis factor-alpha (TNF- α). Through the use of a simple BBB model, results showed that our novel drug delivery system experienced some level of success in targeting the brain inflammation due to increasing TNF-α concentrations. This is promising for drug delivery research and provides support for VCAM-1 targeting using more robust and complex BBB models. | en_US |
dc.identifier.uri | http://hdl.handle.net/1903/13876 | |
dc.language.iso | en_US | en_US |
dc.relation.isAvailableAt | Digital Repository at the University of Maryland | |
dc.relation.isAvailableAt | Gemstone Program, University of Maryland (College Park, Md) | |
dc.subject | Gemstone Team B3 | en_US |
dc.subject | blood brain-barrier | en_US |
dc.subject | vascular cell | en_US |
dc.subject | nanoparticles | en_US |
dc.title | Drug Delivery through the Blood-Brain Barrier through Use of Vascular Cell Adhesion Molecule 1- Targeted Nanoparticles | en_US |
dc.type | thesis | en_US |
Files
Original bundle
1 - 1 of 1