Developing an Extracellular Vesicle Based Treatment for Osteoarthritis

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dc.contributor.advisorJay, Steven M.
dc.contributor.authorBhattacharyya, Sumon
dc.contributor.authorChen, Allison
dc.contributor.authorChill, Stephanie
dc.contributor.authorGolding, Madelyn
dc.contributor.authorLee, Danielle
dc.contributor.authorMumford, Thomas
dc.contributor.authorPu, Alex
dc.contributor.authorRobichaux, Mary
dc.contributor.authorSukri, Kayla
dc.contributor.authorSwayambunathan, Jay
dc.contributor.authorWeigand, Kellen
dc.date.accessioned2018-06-22T17:39:58Z
dc.date.available2018-06-22T17:39:58Z
dc.date.issued2018
dc.description.abstractOsteoarthritis (OA) is a disease characterized by the degradation of articular cartilage. Extracellular vesicles (EVs) are cargo-filled bodies that mediate intercellular communication and are influential in OA pathogenesis. This study utilized parallel methodologies to investigate whether EV signaling can be manipulated to combat OA. The first approach aimed to identify cells lines that produce EVs with therapeutic activity against OA, while the second introduced miRNA in EVs to induce cartilage regeneration. EVs derived from synovial fibroblasts (SFBs) induced further inflammation. Moreover, miRNA did not impact MMP-13 production. While SFB-EVs were pro-inflammatory, increasing the amount of MMP-13 present, human bone marrow-derived mesenchymal stem cell (BM-hMSC) EVs did not stimulate a change in MMP-13 production. Future studies should further characterize these results to maximize therapeutic impact.en_US
dc.identifierhttps://doi.org/10.13016/M2ZP3W36C
dc.identifier.urihttp://hdl.handle.net/1903/20674
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team MATRIXen_US
dc.titleDeveloping an Extracellular Vesicle Based Treatment for Osteoarthritisen_US
dc.typeThesisen_US

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