The controlled delivery of hydrogen sulfide for the preservation of heart tissue

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dc.contributor.advisorFisher, John P.
dc.contributor.authorChen, Elizabeth P.
dc.contributor.authorChiang, Charles G.
dc.contributor.authorGeibel, Elyse M.
dc.contributor.authorGeng, Steven
dc.contributor.authorHung, Stevephen
dc.contributor.authorJee, Kathleen J.
dc.contributor.authorLee, Angela M.
dc.contributor.authorLim, Christine G.
dc.contributor.authorMoghaddam-Taaheri, Sara
dc.contributor.authorPampori, Adam
dc.contributor.authorTang, Kathy
dc.contributor.authorTsai, Jessie
dc.contributor.authorZhong, Diana
dc.date.accessioned2011-05-11T15:25:07Z
dc.date.available2011-05-11T15:25:07Z
dc.date.issued2011
dc.descriptionGemstone Team Organ Storage and Hibernationen_US
dc.description.abstractThere are over 100,000 patients on organ transplant waiting lists, creating a significant need to expand the donor pool. The heart is the most difficult organ to preserve ex vivo, with a short viable storage time of 4-6 hours, because damage to mitochondria during preservation can impair the heart's contractile function. By extending the viability time, the geographical range of donors can be extended. Hydrogen sulfide (H2S) has been shown to reduce metabolism, increase preservation times, and enhance graft viability. We have developed gelatin microspheres under 10 microns able to slowly release H2S and investigated different crosslinking concentrations to understand the time release profiles. These microspheres were then used to maintain H2S levels in cardiomyocyte cell cultures without decreasing cell viability. Histological samples from 20 cold-stored rat hearts in various experimental treatments show H2S-releasing microspheres offer protection against preservation injury comparable to the current clinical standard, University of Wisconsin solution.en_US
dc.identifier.urihttp://hdl.handle.net/1903/11383
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectorgan transplanten_US
dc.subjecthearten_US
dc.subjectstorageen_US
dc.subjecthydrogen sulfideen_US
dc.subjectGemstone Team Organ Storage and Hibernationen_US
dc.titleThe controlled delivery of hydrogen sulfide for the preservation of heart tissueen_US
dc.typeThesisen_US

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