Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan

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dc.contributor.advisorPerez, Danielen_US
dc.contributor.authorPadmanabhan, Rangarajanen_US
dc.contributor.departmentCell Biology & Molecular Geneticsen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2009-07-03T05:44:38Z
dc.date.available2009-07-03T05:44:38Z
dc.date.issued2009en_US
dc.description.abstractContinuous surveillance of influenza becomes important considering the economic, epidemic and pandemic implications of influenza infections. This study details phylogenetic & molecular analysis of the genes of four swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan. Phylogenetic analysis placed the eight segments of the four viruses in the classical H1N1 swine clade, along with the isolate A/sw/Jamesburg/1942, except for the HA of A/Alma-Ata/32/98, which was placed in the human H1N1 lineage, along with the isolate A/WS/1933. On amino acid analysis, the viruses displayed mutations on HA and ribonucleoproteins which putatively disrupt antigenic recognition of the virus by the host immune system. The presence of these viruses relatively unchanged for 6 decades after their initial isolation could be speculated to be a combination of laboratory leaks in southern USSR in 1980s, low divergence of classical H1N1 viruses in pigs, and the low population density of Kazakhstan.en_US
dc.format.extent903016 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/9355
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Microbiologyen_US
dc.subject.pquncontrolledevolutionary reservoiren_US
dc.subject.pquncontrolledInfluenzaen_US
dc.subject.pquncontrolledKazakhstanen_US
dc.subject.pquncontrolledlaboratory leaken_US
dc.subject.pquncontrolledpersistenceen_US
dc.titlePhylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstanen_US
dc.typeThesisen_US

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