SPRAYABLE, BIODEGRADABLE POLYMER BLENDS FOR TISSUE ADHESION

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dc.contributor.advisorKofinas, Peteren_US
dc.contributor.authorDaristotle, John Len_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2020-02-01T06:41:48Z
dc.date.available2020-02-01T06:41:48Z
dc.date.issued2019en_US
dc.description.abstractTissue adhesive materials can revolutionize surgical procedures, but they are often difficult to apply safely because of a required curing step where the viscous components of a glue solidify and become sticky. To simplify their deposition and improve their usability, this dissertation introduces tissue adhesive polymer blends that can be sprayed using a fiber production technique called solution blow spinning. The polymer blends studied here are innovative because they are non-curing: the polymer accumulates as a solid material directly on the tissue substrate of interest during spraying, quickly forming a strong bond. To achieve a rapid increase in tissue adhesion, we developed a surgical sealant composed of poly(lactic-co-glycolic acid) and poly(ethylene glycol) (PLGA/PEG) that becomes adhesive in response to warming to body temperature. We then evaluated PLGA/PEG in small and large animal models of intestinal anastomosis and partial thickness skin wounds. Additional improvements to hemostasis, flexibility, and adhesion were made by incorporating micron-sized silica particles, which produced textured fibers with suppressed crack formation. We also developed the first pressure-sensitive tissue adhesive by formulating elastomeric copolymer blends with two components of different molecular weights. An additional objective of this dissertation was to study sprayable polymers that can be used as a controlled release system for various drugs. Towards this goal, we incorporated antimicrobial silver into solution blow spun PLGA/PEG fibers. At the optimal concentration, silver ions released over 14 days at levels that were effectively antimicrobial with minimal cytotoxicity. Coating strategies for controlling the delivery of polyelectrolyte complexes were also investigated.en_US
dc.identifierhttps://doi.org/10.13016/wswa-yjsw
dc.identifier.urihttp://hdl.handle.net/1903/25458
dc.language.isoenen_US
dc.subject.pqcontrolledBioengineeringen_US
dc.subject.pqcontrolledMaterials Scienceen_US
dc.subject.pqcontrolledPolymer chemistryen_US
dc.subject.pquncontrolledpolymer blendsen_US
dc.subject.pquncontrolledsolution blow spinningen_US
dc.subject.pquncontrolledsurgical sealanten_US
dc.subject.pquncontrolledtissue adhesionen_US
dc.subject.pquncontrolledwound healingen_US
dc.titleSPRAYABLE, BIODEGRADABLE POLYMER BLENDS FOR TISSUE ADHESIONen_US
dc.typeDissertationen_US

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