Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning

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dc.contributor.authorChan, Wilson
dc.contributor.authorSingh, Sanmeet
dc.contributor.authorKeshav, Taj
dc.contributor.authorDewan, Ramita
dc.contributor.authorEberly, Christian
dc.contributor.authorMaurer, Robert
dc.contributor.authorNunez-Parra, Alexia
dc.contributor.authorAraneda, Ricardo C.
dc.date.accessioned2017-08-31T19:55:31Z
dc.date.available2017-08-31T19:55:31Z
dc.date.issued2017-02-02
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.en_US
dc.description.abstractThe cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating the excitability of OB neurons, in particular the M1 receptor. Here, we examined the contribution of M1 and M3 mAChR subtypes to olfactory processing using mice with a genetic deletion of these receptors, the M1-/- and the M1/M3-/- knockout (KO) mice. Genetic ablation of the M1 and M3 mAChRs resulted in a significant deficit in odor discrimination of closely related molecules, including stereoisomers. However, the discrimination of dissimilar molecules, social odors (e.g., urine) and novel object recognition was not affected. In addition the KO mice showed impaired learning in an associative odor-learning task, learning to discriminate odors at a slower rate, indicating that both short and long-term memory is disrupted by mAChR dysfunction. Interestingly, the KO mice exhibited decreased olfactory neurogenesis at younger ages, a deficit that was not maintained in older animals. In older animals, the olfactory deficit could be restored by increasing the number of new born neurons integrated into the OB after exposing them to an olfactory enriched environment, suggesting that muscarinic modulation and adult neurogenesis could be two different mechanism used by the olfactory system to improve olfactory processing.en_US
dc.identifierhttps://doi.org/10.13016/M2ST7DX2R
dc.identifier.citationChan W, Singh S, Keshav T, Dewan R, Eberly C, Maurer R, Nunez-Parra A and Araneda RC (2017) Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning. Front. Synaptic Neurosci. 9:4. doi: 10.3389/fnsyn.2017.00004en_US
dc.identifier.urihttp://hdl.handle.net/1903/19715
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtBiologyen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectolfactoryen_US
dc.subjectgranule cellen_US
dc.subjectinhibitionen_US
dc.subjectolfactory discriminationen_US
dc.subjectadult neurogenesisen_US
dc.titleMice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learningen_US
dc.typeArticleen_US

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