EFFECTS OF SUGAR SOLUTIONS ON HYPOTHALAMIC APPETITE REGULATION

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dc.contributor.advisorCastonguay, Thomas Wen_US
dc.contributor.authorColley, Danielle Louiseen_US
dc.contributor.departmentNutritionen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2013-07-04T05:33:15Z
dc.date.available2013-07-04T05:33:15Z
dc.date.issued2013en_US
dc.description.abstractThere are multiple hypotheses for the causes of the obesity epidemic. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine some the unique metabolic changes that occur with initial exposure to dilute glucose, sucrose, high fructose corn syrup, or fructose solutions. Rats were given access to food, water and a sugar solution for 24 h, after which blood and tissues were collected. Fructose access (as opposed to other sugars investigated) resulted in a doubling of circulating triglycerides. Glucose consumption resulted in upregulation of 7 satiety related hypothalamic peptides whereas changes in gene expression were mixed for remaining sugars. Also, following multiple verification assays, 6 satiety related peptides were verified as being affected by sugar intake. These data provide evidence that not all sugars are equally effective in affecting the control of intake.en_US
dc.identifier.urihttp://hdl.handle.net/1903/14303
dc.subject.pqcontrolledNutritionen_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pqcontrolledMolecular biologyen_US
dc.subject.pquncontrolledappetite regulationen_US
dc.subject.pquncontrolledfructoseen_US
dc.subject.pquncontrolledhypothalamusen_US
dc.subject.pquncontrolledintakeen_US
dc.subject.pquncontrolledpeptidesen_US
dc.titleEFFECTS OF SUGAR SOLUTIONS ON HYPOTHALAMIC APPETITE REGULATIONen_US
dc.typeThesisen_US

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