Given extensive evidence about the importance of relationships with friends during development, a large body of research has examined the correlates of these significant social experiences. Most of this research, however, has examined either individual characteristics (e.g., behavior, personality) or contextual factors (e.g., family), and most of the work has studied relationships during childhood. The present study extended previous research by examining how both an individual factor (adolescent distress tolerance) and a contextual factor (parental response to adolescent distress) are linked to adolescents’ friendships. Adolescents (N = 161) completed two behavioral measures of distress tolerance, and parents reported about their responses to adolescent distress. Although distress tolerance and parental responses to distress were not directly associated with adolescents’ positive or negative friendship experiences, for adolescents with low distress tolerance, harsh parental responses were negatively associated with adolescents’ positive friendship quality. Further, for adolescents whose parents used harsh responses to distress, distress tolerance was negatively associated with adolescents’ positive friendship quality. Results highlight the importance of studying both individual and familial factors related to adolescents’ social functioning. (APA PsycInfo Database Record (c) 2016 APA, all rights reserved)