CerviCare: A Point of Care Screening Device for Cervical Precancer

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dc.contributor.advisorKahn, Jason
dc.contributor.advisorEisenstein, Edward
dc.contributor.authorBansal, Navya
dc.contributor.authorFirdaus, Sarah
dc.contributor.authorJocić, Mia
dc.contributor.authorMeyer, Jonathon
dc.contributor.authorValdés, Trinidad Cubillos
dc.contributor.authorWu, Jonathan
dc.contributor.authorJaranson, Renee
dc.contributor.authorZhang, Kevin
dc.contributor.authorFerguson, Graham
dc.contributor.authorAdu-Osei, Krista
dc.contributor.authorNamputhiripad, Aditi
dc.contributor.authorHarel, Dana
dc.contributor.authorLu, Rebecca
dc.contributor.authorHussain, Haider
dc.contributor.authorWang, Miranda
dc.contributor.authorGadigi, Aditri
dc.contributor.authorSenthilkumar, Abhi
dc.date.accessioned2024-04-18T14:58:51Z
dc.date.available2024-04-18T14:58:51Z
dc.date.issued2024-04
dc.description.abstractCervical cancer remains a significant health burden, especially in regions with limited access to diagnostic facilities. To combat this, the UMaryland iGEM Team is developing an inexpensive point-of-care cervical precancer screening tool. Utilizing red fluorescent protein (RFP), this tool will provide a reliable color-based output upon detecting specific miRNAs (miR-21, miR-199a, and miR-155-5p) associated with cervical precancer. Our detection approach combines toehold switch and novel synthetic RNA technologies. Toehold switches serve as recognition elements, enabling target miRNA detection with high sensitivity and specificity. Our synthetic RNA ribozyme device will utilize both a novel miRNA sensor and self-cleaving properties to achieve similar sensitivity and specificity. Utilizing two cell-free devices in tandem will allow us to increase the accuracy of our screening device, which will be a paper assay system. Finally, through careful design and optimization, we aim to produce this device at low-cost and simplify it to require minimal training, enabling its use in resource-limited areas.
dc.description.sponsorshipiGEM at the University of Maryland Fischell Department of Bioengineering A. James Clark School of Engineering College of Computer, Mathematical, and Natural Sciences
dc.identifierhttps://doi.org/10.13016/j5d6-hlxe
dc.identifier.urihttp://hdl.handle.net/1903/32521
dc.language.isoen_US
dc.publisheriGEM
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.relation.isAvailableAtOffice of Undergraduate Research
dc.subjectbioengineering
dc.subjectundergraduate research
dc.subjectigem
dc.subjectsynthetic biology
dc.subjectcervicare
dc.subjectcervical cancer
dc.subjectscreening
dc.subjectoncology
dc.subjectglobal health equity
dc.titleCerviCare: A Point of Care Screening Device for Cervical Precancer
dc.typePresentation
local.equitableAccessSubmissionNo

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