Mating can initiate stable RNA silencing that overcomes epigenetic recovery

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dc.contributor.authorDevanapally, Sindhuja
dc.contributor.authorRaman, Pravrutha
dc.contributor.authorChey, Mary
dc.contributor.authorAllgood, Samual
dc.contributor.authorEttefa, Farida
dc.contributor.authorDiop, Maïgane
dc.contributor.authorLin, Yixin
dc.contributor.authorCho, Yongyi E.
dc.contributor.authorJose, Antony M.
dc.date.accessioned2022-06-10T15:00:11Z
dc.date.available2022-06-10T15:00:11Z
dc.date.issued2021-07-09
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund
dc.description.abstractStable epigenetic changes appear uncommon, suggesting that changes typically dissipate or are repaired. Changes that stably alter gene expression across generations presumably require particular conditions that are currently unknown. Here we report that a minimal combination of cis-regulatory sequences can support permanent RNA silencing of a singlecopy transgene and its derivatives in C. elegans simply upon mating. Mating disrupts competing RNA-based mechanisms to initiate silencing that can last for >300 generations. This stable silencing requires components of the small RNA pathway and can silence homologous sequences in trans. While animals do not recover from mating-induced silencing, they often recover from and become resistant to trans silencing. Recovery is also observed in most cases when double-stranded RNA is used to silence the same coding sequence in different regulatory contexts that drive germline expression. Therefore, we propose that regulatory features can evolve to oppose permanent and potentially maladaptive responses to transient change.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-24053-4
dc.identifierhttps://doi.org/10.13016/fnqu-bj8w
dc.identifier.citationDevanapally, S., Raman, P., Chey, M. et al. Mating can initiate stable RNA silencing that overcomes epigenetic recovery. Nat Commun 12, 4239 (2021).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28658
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCell Biology & Molecular Geneticsen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.titleMating can initiate stable RNA silencing that overcomes epigenetic recoveryen_US
dc.typeArticleen_US

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