TRPV4, a calcium-permeable channel, regulates oxidized LDL-induced macrophage foam cell formation

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dc.contributor.advisorRahaman, Shaik O.en_US
dc.contributor.authorGoswami, Rishoven_US
dc.contributor.departmentNutritionen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2018-01-25T06:35:09Z
dc.date.available2018-01-25T06:35:09Z
dc.date.issued2017en_US
dc.description.abstractAccumulation of lipid-laden “macrophage foam cell” in the arterial wall is the hallmark of atherosclerosis that leads to the highest number of cardiovascular disease-related deaths in United States. Membrane scavenger receptors such as SR-A, and CD36 play important role in controlling oxidized low-density lipoprotein binding and uptake, and, thereby, in macrophage foam cell formation. Recent studies also put emphasis on the role of mechanical factors, such as matrix stiffness, in the regulation of macrophage function and atherogenesis. However, the identity of a plasma membrane mechanosensor and the underlying mechanisms that may promote atherogenesis is yet to be identified. We have found that a calcium-permeable plasma membrane protein TRPV4, a mechanosensor, may play an essential role in regulating macrophage foam cell formation, a critical process in atherosclerosis. We have also found that TRPV4 is essential for oxLDL uptake, but not for its binding. Altogether, herein, we demonstrate that TRPV4 plays a critical role in macrophage-foam-cell formation by regulating oxLDL uptake in cells.en_US
dc.identifierhttps://doi.org/10.13016/M28P5VB6N
dc.identifier.urihttp://hdl.handle.net/1903/20438
dc.language.isoenen_US
dc.subject.pqcontrolledCellular biologyen_US
dc.subject.pqcontrolledBiochemistryen_US
dc.subject.pqcontrolledNutritionen_US
dc.titleTRPV4, a calcium-permeable channel, regulates oxidized LDL-induced macrophage foam cell formationen_US
dc.typeThesisen_US

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