The Effect of Architecture and Shear Stress on Endothelialization of 3D Printed Vascular Networks

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dc.contributor.advisorFisher, John Pen_US
dc.contributor.authorTalaie, Taraen_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2016-09-03T05:31:08Z
dc.date.available2016-09-03T05:31:08Z
dc.date.issued2016en_US
dc.description.abstractDespite significant progress in the field of tissue engineering within the last decade, a number of unsolved problems still remain. One of the most relevant issues is the lack of proper vascularization that limits the size of engineered tissues to smaller than clinically relevant dimensions. In particular, the growth of engineered tissue in vitro within bioreactors is plagued with this challenge. Specifically, the tubular perfusion system bioreactor has been used for large scale bone constructs; however these engineered constructs lack inherent vasculature and quickly develop a hypoxic core, where no nutrient exchange can occur, thus leading to cell death. Through the use of 3D printed vascular templates in conjunction with a tubular perfusion system bioreactor, we attempt to create an endothelial cell monolayer on 3D scaffolds that could potentially serve as the foundation of inherent vasculature within these engineered bone grafts.en_US
dc.identifierhttps://doi.org/10.13016/M20V3D
dc.identifier.urihttp://hdl.handle.net/1903/18528
dc.language.isoenen_US
dc.subject.pqcontrolledBiomedical engineeringen_US
dc.subject.pquncontrolled3D printingen_US
dc.subject.pquncontrolledbioreactorsen_US
dc.subject.pquncontrolledendothelial cellsen_US
dc.subject.pquncontrolledHUVECen_US
dc.subject.pquncontrolledTissue engineeringen_US
dc.subject.pquncontrolledtissue graftsen_US
dc.titleThe Effect of Architecture and Shear Stress on Endothelialization of 3D Printed Vascular Networksen_US
dc.typeThesisen_US

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