MRI Processing Pipeline Variability and Infant Brain Morphometry Associations to 4-Month Infant Temperament

Simple item page
dc.contributor.advisorFox, Nathan
dc.contributor.advisorFilippi, Courtney
dc.contributor.authorFoster, Kayla
dc.contributor.authorFilippi, Courtney
dc.contributor.authorMargolis, Emma
dc.contributor.authorRavi, Sanjana
dc.contributor.authorBracy, Maya
dc.contributor.authorPine, Daniel
dc.contributor.authorFox, Nathan
dc.date.accessioned2020-04-27T00:51:25Z
dc.date.available2020-04-27T00:51:25Z
dc.date.issued2020
dc.description.abstractNegative reactive temperament, an infant temperament characterized by fear of novelty, is associated with adolescent amygdala volume (Filippi et al, 2020) and adult prefrontal cortex (PFC) thickness (Schwartz et al, 2010). However, it remains unknown whether these differences in brain morphometry emerge in infancy. Further, evaluating this possibility is a challenge because few pipelines are optimized for processing infant magnetic resonance imaging (MRI) data. Thus, evaluation of available infant MRI processing pipelines is necessary prior to examining associations between negative reactivity and brain morphometry. This study examines (1) which MRI pipeline performs best for 4-month-old infant MRI data and (2) associations between temperament and brain morphometry. Behavioral reactivity was assessed by presenting novel stimuli to infants. High-resolution structural MRI data was acquired a few weeks later. MRI data were processed using the iBEAT (Dai et al, 2013), dHCP (Makropoulos et al, 2018), and CIVET (Ad-Dab’bagh et al., 2006) pipelines to obtain estimates of amygdala and PFC volume. The quality of segmentations of the three pipelines was then assessed. The processing pipelines showed differences in terms of quality of gray/white segmentation and percentage of processing failures. Overall, iBEAT performed the best with the highest percent of useable data. Using the iBEAT output, we examined the associations between infant brain morphometry and reactivity. Results indicated no significant association between amygdala or PFC volume and reactivity.en_US
dc.identifierhttps://doi.org/10.13016/etu6-qohr
dc.identifier.urihttp://hdl.handle.net/1903/25902
dc.language.isoen_USen_US
dc.relation.isAvailableAtMaryland Center for Undergraduate Research
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectHuman Development and Quantitative Methodologyen_US
dc.subjectEDUCen_US
dc.subjectFosteren_US
dc.subjectMaryland Summer Scholarsen_US
dc.subjectInfant temperamenten_US
dc.subjectMagnetic Resonance Imaging (MRI)en_US
dc.subjectBrain morphometryen_US
dc.titleMRI Processing Pipeline Variability and Infant Brain Morphometry Associations to 4-Month Infant Temperamenten_US
dc.typePresentationen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
MRI Processing Pipelines and 4-Month Infant Temperament.pdf
Size:
676.61 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Undergraduate Research Day 2020