A Study of pH Manipulation on Tumor Proliferation and the CTL Response

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dc.contributor.advisorXiao, Zhengguo
dc.contributor.authorBeg, Subul
dc.contributor.authorChang, Alice
dc.contributor.authorEgan, Ciara
dc.contributor.authorFeleke-Eshete, Lienna
dc.contributor.authorKao, Allen
dc.contributor.authorMartinson, James
dc.contributor.authorSehareen, Saadiya
dc.contributor.authorTunick, Benjamin
dc.contributor.authorWainger, Julia
dc.date.accessioned2016-06-15T12:36:14Z
dc.date.available2016-06-15T12:36:14Z
dc.date.issued2016-05
dc.description.abstractAdoptive Cell Transfer (ACT) Therapy is a cancer treatment that enhances and utilizes the body’s own immune system. However, this treatment has had limited success in clinical trials. We hypothesized that this is due to the immunosuppressive, acidic microenvironment of cancer tumors. We tested the effects of acidic, neutral, and basic environments in vitro on cytotoxic T lymphocyte (CTL) survival, activation, migration and killing ability and on cancer cell survival. We found that CTLs have most optimum survival, activation, and migration in a neutral environment, while the optimal extracellular conditions for EG-7 lymphoma are slightly acidic and B16-OVA melanoma survives best in physiological conditions. Future research should further study the killing ability of T cells in the three different environments and look to move to in vivo experiments.en_US
dc.identifierhttps://doi.org/10.13016/M2019D
dc.identifier.urihttp://hdl.handle.net/1903/18095
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team BASICen_US
dc.subjectAdoptive Cell Transfer Therapy (ACT)en_US
dc.subjectcancer treatmenten_US
dc.subjectcytotoxic T lymphocyteen_US
dc.subjectpHen_US
dc.titleA Study of pH Manipulation on Tumor Proliferation and the CTL Responseen_US
dc.typeThesisen_US

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