REGULATORY EFFECTS OF ACUTE AND CHRONIC ENDURANCE EXERCISE ON NITRIC OXIDE AND REACTIVE OXYGEN SPECIES IN HUMAN CIRCULATING ANGIOGENIC CELLS

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dc.contributor.advisorHagberg, James Men_US
dc.contributor.authorJenkins, Nathan Thomasen_US
dc.contributor.departmentKinesiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2011-10-08T05:39:50Z
dc.date.available2011-10-08T05:39:50Z
dc.date.issued2011en_US
dc.description.abstractThis dissertation research comprised three studies examining the effects of acute and chronic endurance exercise on circulating angiogenic cells (CACs). Because the balance between nitric oxide (NO) and reactive oxygen species (ROS) is a critical aspect of the physiological function/dysfunction of CACs, each study determined the effects of exercise on NO-ROS balance within a variety of CAC types. Study #1 demonstrated that regular endurance exercise is associated with greater basal intracellular NO levels in cultured CACs, and that one mechanism underlying this association was increased NADPH oxidase enzyme activity in the sedentary state. Study #2 suggested an association between a sedentary lifestyle and increased nitro-oxidative stress in freshly-isolated CD34+ progenitor cells. Study #3 demonstrated that prior exercise attenuates high-fat meal induced-increases in mitochondrial-derived intracellular ROS in CD31+ CACs. Overall, it is concluded that acute and chronic endurance exercise enhance intracellular NO and ROS dynamics in CACs.en_US
dc.identifier.urihttp://hdl.handle.net/1903/11897
dc.subject.pqcontrolledKinesiologyen_US
dc.subject.pqcontrolledPhysiologyen_US
dc.subject.pqcontrolledCellular biologyen_US
dc.subject.pquncontrolledangiogenesisen_US
dc.subject.pquncontrolledcardiovascular diseaseen_US
dc.subject.pquncontrolledexerciseen_US
dc.subject.pquncontrollednitric oxideen_US
dc.subject.pquncontrolledoxidative stressen_US
dc.subject.pquncontrolledprogenitor cellen_US
dc.titleREGULATORY EFFECTS OF ACUTE AND CHRONIC ENDURANCE EXERCISE ON NITRIC OXIDE AND REACTIVE OXYGEN SPECIES IN HUMAN CIRCULATING ANGIOGENIC CELLSen_US
dc.typeDissertationen_US

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