Interferense of Host Innate Immune Response by Hepatitis E Virus

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dc.contributor.advisorZhang, Yanjinen_US
dc.contributor.authorNan, Yuchenen_US
dc.contributor.departmentVeterinary Medical Scienceen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2014-10-16T05:36:41Z
dc.date.available2014-10-16T05:36:41Z
dc.date.issued2014en_US
dc.description.abstractThe host antiviral innate immunity mainly relies on host pattern recognition receptors (PRR) and downstream interferon (IFN) signaling. Host PRR for RNA viruses include Toll-like receptors (TLR) and Retinoic acid-inducible gene I (RIG-I) like receptors (RLR). Activation of both TLR and RLR pathways can eventually lead to the secretion of type I IFNs, which can modulate both innate and adaptive immune responses against viral pathogens, including hepatitis E virus (HEV). HEV causes acute hepatitis in humans and has been responsible for several outbreaks of hepatitis across the world. Currently, no commercial vaccine is available for the prevention of HEV infection in any country except China. HEV biology and pathogenesis as well as its responses to host innate immunity are poorly understood, though other hepatitis viruses, including the hepatitis A, B and C viruses, have been much better studied. In this study, how HEV interferes with IFN induction and IFN-activated signaling had been examined. Results showed that the protein encoded by HEV ORF1 can inhibit type I IFN synthesis and downstream JAK/STAT signaling pathway. However, the HEV ORF3 product is able to enhance RIG-I-mediated signaling to a certain extent. These data suggest that HEV proteins interfere with the host innate immune response and may exert the diverse roles depending on the stage and/or context of infection. These studies contribute to a better understanding of HEV pathogenesis and may facilitate a strategy development for the prevention and control of HEV infection.en_US
dc.identifierhttps://doi.org/10.13016/M2SW3W
dc.identifier.urihttp://hdl.handle.net/1903/15898
dc.language.isoenen_US
dc.subject.pqcontrolledVirologyen_US
dc.subject.pquncontrolledHepatitis E virusen_US
dc.subject.pquncontrolledHEVen_US
dc.subject.pquncontrolledInnate Immunityen_US
dc.subject.pquncontrolledInterferonsen_US
dc.subject.pquncontrolledRIG-I like Receptorsen_US
dc.titleInterferense of Host Innate Immune Response by Hepatitis E Virusen_US
dc.typeDissertationen_US

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