Developing A Broadly Protective MRNA Influenza Vaccine: A Review

dc.contributor.advisorYarwood, Stephanie
dc.contributor.authorAcquah, Wellington
dc.contributor.authorAmini, Cameron
dc.contributor.authorBuddula, Saharsh
dc.contributor.authorChen, Michelle
dc.contributor.authorChintala, Navya
dc.contributor.authorDang, Quinn
dc.contributor.authorFerziger, Noa
dc.contributor.authorHollis, Grace
dc.contributor.authorJameison, Devin
dc.contributor.authorJayaram, Jyostna
dc.contributor.authorManus, Joseph Anthony
dc.contributor.authorRosenberg, Jacob
dc.contributor.authorZhiteneva, Julia
dc.date.accessioned2022-08-31T19:38:00Z
dc.date.available2022-08-31T19:38:00Z
dc.date.issued2022
dc.descriptionGemstone Team MUTATEen_US
dc.description.abstractCurrent influenza vaccines are limited in their efficacy due to antigenic drift of the hemagglutinin target; advances in mRNA vaccines in response to the COVID-19 pandemic may provide a new direction for influenza vaccine development. Existing literature shows that mRNA vaccines have higher efficacy in preventing illness, hospitalizations, and death. We evaluated eleven influenza A viral proteins as potential targets for an mRNA vaccine under the following criteria: degree of conservation, ability to elicit a robust immune response, and ability to prevent illness and death. We recommend future researchers direct their efforts towards developing an annually administered tri-sequence mRNA vaccine targeting hemagglutinin head (HA1), the matrix 2 ectodomain (M2e), and nucleoprotein (NP). Development of a highly effective influenza mRNA vaccine would be significant for prevention of disease burden worldwide.en_US
dc.identifierhttps://doi.org/10.13016/zqve-whgp
dc.identifier.urihttp://hdl.handle.net/1903/29108
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team MUTATEen_US
dc.titleDeveloping A Broadly Protective MRNA Influenza Vaccine: A Reviewen_US
dc.typeThesisen_US

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