The Development of EH Networks for Skeletal Muscle Regeneration within Abdominal Wall Hernias

Simple item page
dc.contributor.advisorFisher, John Pen_US
dc.contributor.authorFalco, Erin E.en_US
dc.contributor.departmentChemical Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2007-06-22T05:37:27Z
dc.date.available2007-06-22T05:37:27Z
dc.date.issued2007-05-02
dc.description.abstractIncisional hernias are a common clinical problem occurring in up to 10% of all patients undergoing abdominal incisions. Current repair techniques involve the placement of xenografts, allografts, or prosthetic biomaterials. Despite these techniques, the incidence of hernia recurrence ranges from 24% to 54%. In order to address these high recurrence rates, we propose using a skeletal muscle engineering strategy. To this end, the novel cyclic acetal biomaterial, 5-ethyl-5-(hydroxymethyl)-β,β-dimethyl-1,3-dioxane-2-ethanol diacrylate, was functionalized to promote skeletal muscle regeneration. It was found that this biomaterial promotes myoblastic cell attachment and proliferation as well as the delivery of functional insulin-like growth factor 1 proteins <em>in vitro</em>; therefore demonstrating the scaffolds biocompatibility. Furthermore, mechanical properties of the scaffold were tested and the complex modulus was shown to decrease after a significant increase in initiator concentration. Overall, this work establishes the functionality of a degradable cyclic acetal as a scaffold for skeletal muscle engineering.en_US
dc.format.extent386429 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/6921
dc.language.isoen_US
dc.subject.pqcontrolledEngineering, Chemicalen_US
dc.subject.pquncontrolledSkeletal Muscleen_US
dc.subject.pquncontrolledAbdominal Wall Herniaen_US
dc.subject.pquncontrolledCyclic Acetalen_US
dc.subject.pquncontrolledProsthetic Meshesen_US
dc.subject.pquncontrolledInsulin Like Growth Factor-1en_US
dc.titleThe Development of EH Networks for Skeletal Muscle Regeneration within Abdominal Wall Herniasen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
umi-umd-4420.pdf
Size:
377.37 KB
Format:
Adobe Portable Document Format
Download

Collections

UMD Theses and Dissertations
Chemical and Biomolecular Engineering Theses and Dissertations