Closed-Loop Fluid Resuscitation: In-Silico Study
dc.contributor.advisor | Hahn, Jin-Oh | en_US |
dc.contributor.author | Lucas, Jon | en_US |
dc.contributor.department | Mechanical Engineering | en_US |
dc.contributor.publisher | Digital Repository at the University of Maryland | en_US |
dc.contributor.publisher | University of Maryland (College Park, Md.) | en_US |
dc.date.accessioned | 2016-02-09T06:36:58Z | |
dc.date.available | 2016-02-09T06:36:58Z | |
dc.date.issued | 2015 | en_US |
dc.description.abstract | This thesis validates a control-oriented model of human circulatory dynamics associated with hemorrhage and fluid resuscitation, uses this model to design a series of closed-loop controllers for fluid resuscitation, and demonstrates the viability of these controllers by examining the performance of these controllers in an established model of human cardiovascular physiology. First, a recently developed control-oriented model of hemorrhage and fluid resuscitation was validated across diverse physiological conditions using an established model of human cardiovascular physiology, by employing a system identification procedure. Second, a series of closed-loop controllers were designed based on the nominal control-oriented model, including proportional control and proportional-derivative control based on the root locus analysis, as well as observer-based optimal state feedback control based on modern control theory. Third, the performance and robustness of the designed closed-loop controllers were validated using the established model of human cardiovascular physiology. The results suggested that model-based closed-loop control may be a viable alternative to today’s manual fluid infusion practices. | en_US |
dc.identifier | https://doi.org/10.13016/M2FQ5T | |
dc.identifier.uri | http://hdl.handle.net/1903/17389 | |
dc.language.iso | en | en_US |
dc.subject.pqcontrolled | Mechanical engineering | en_US |
dc.subject.pquncontrolled | blood volume dynamics | en_US |
dc.subject.pquncontrolled | closed-loop fluid resuscitation | en_US |
dc.subject.pquncontrolled | control-oriented blood volume | en_US |
dc.title | Closed-Loop Fluid Resuscitation: In-Silico Study | en_US |
dc.type | Thesis | en_US |
Files
Original bundle
1 - 1 of 1