ARRHYTHMOGENESIS AND CONDUCTION PROPERTIES OF CARDIOMYOCYTES IN RESPONSE TO DYSSYNCHRONOUS MECHANICAL AND ELECTRICAL STIMULATION

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dc.contributor.advisorBentley, William Een_US
dc.contributor.authorChan, Dulcianaen_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2011-02-19T07:12:15Z
dc.date.available2011-02-19T07:12:15Z
dc.date.issued2010en_US
dc.description.abstractMany cardiac therapeutic modalities, including pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therapy devices, are used to treat abnormalities in cardiac function and conduction. Both electrical and mechanical dyssynchrony can have deleterious effects including reduced cardiac output and an increased susceptibility to cardiac arrhythmias. It is postulated that electro-mechanical dyssynchrony may contribute to the susceptibility of the heart to cardiac arrhythmias. In this study, a novel system was developed to study these effects by altering the electro-mechanical activation sequence in cultured neonatal rat cardiomyocyte monolayers by dyssynchronously stimulating the monolayers with applied electrical fields and pulsatile mechanical strain. Specifically, optical mapping was utilized to compare action potential duration and quantify arrhythmia susceptibility of cardiomyocytes subjected to pulsatile mechanical strain, electrical stimulation, and dyssynchronous electrical and mechanical stimulation. This system provides a method to evaluate changes in cardiomyocyte conduction properties due to altered electro-mechanical coupling and the subsequent impact on arrhythmogenesis.en_US
dc.identifier.urihttp://hdl.handle.net/1903/11254
dc.subject.pqcontrolledBiomedical Engineeringen_US
dc.subject.pqcontrolledPhysiologyen_US
dc.subject.pqcontrolledBiophysicsen_US
dc.subject.pquncontrolledarrhythmiaen_US
dc.subject.pquncontrolledcardiomyocyteen_US
dc.subject.pquncontrolledconductionen_US
dc.subject.pquncontrolleddyssynchronousen_US
dc.subject.pquncontrolledelectrical stimulationen_US
dc.subject.pquncontrolledmechanical strainen_US
dc.titleARRHYTHMOGENESIS AND CONDUCTION PROPERTIES OF CARDIOMYOCYTES IN RESPONSE TO DYSSYNCHRONOUS MECHANICAL AND ELECTRICAL STIMULATIONen_US
dc.typeThesisen_US

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