Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus

dc.contributor.authorGammerdinger, William J.
dc.contributor.authorConte, Matthew A.
dc.contributor.authorAcquah, Enoch A.
dc.contributor.authorRoberts, Reade B.
dc.contributor.authorKocher, Thomas D.
dc.descriptionFunding for Open Access provided by the UMD Libraries Open Access Publishing Fund.
dc.description.abstractSex-determination genes drive the evolution of adjacent chromosomal regions. Sexually antagonistic selection favors the accumulation of inversions that reduce recombination in regions adjacent to the sex-determination gene. Once established, the clonal inheritance of sex-linked inversions leads to the accumulation of deleterious alleles, repetitive elements and a gradual decay of sex-linked genes. This in turn creates selective pressures for the evolution of mechanisms that compensate for the unequal dosage of gene expression. Here we use whole genome sequencing to characterize the structure of a young sex chromosome and quantify sex-specific gene expression in the developing gonad. We found an 8.8 Mb block of strong differentiation between males and females that corresponds to the location of a previously mapped sex-determiner on linkage group 1 of Oreochromis niloticus. Putatively disruptive mutations are found in many of the genes within this region. We also found a significant female-bias in the expression of genes within the block of differentiation compared to those outside the block of differentiation. Eight candidate sex-determination genes were identified within this region. This study demonstrates a block of differentiation on linkage group 1, suggestive of an 8.8 Mb inversion encompassing the sex-determining locus. The enrichment of female-biased gene expression inside the proposed inversion suggests incomplete dosage compensation. This study helps establish a model for studying the early-to-intermediate stages of sex chromosome evolution.en_US
dc.identifier.citationGammerdinger, W.J., Conte, M.A., Acquah, E.A. et al. Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus. BMC Genomics 15, 975 (2014).en_US
dc.publisherBioMed Centralen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.titleStructure and decay of a proto-Y region in Tilapia, Oreochromis niloticusen_US


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