Novel Endoscope for Surgical Guidance and Functional Brain Imaging

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dc.contributor.advisorChen, Yuen_US
dc.contributor.authorTang, Qinggong Tangen_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2017-09-13T05:30:58Z
dc.date.available2017-09-13T05:30:58Z
dc.date.issued2017en_US
dc.description.abstractOptical imaging methods have become very powerful tools in biomedical research since they can achieve both high spatial and temporal resolutions. However, due to the effects of light scattering, the penetration depth of optical imaging methods is usually limited. Gradient refractive index (GRIN) lens that are 350–2,000 μm in diameter and provide micron-scale resolution have been shown to enable minimally invasive in vivo imaging of deep tissues. Based on GRIN lens, we developed a small hand-held optical coherence tomography (OCT) forward-imaging needle device for real-time epidural anesthesia surgery guidance and demonstrated its feasibility through ex vivo and in vivo animal experiments. Besides, to access subcortical brain structures, we combined voltage-sensitive dye imaging (VSDi) with GRIN lens to image neural activities evoked in thalamic barreloids by deflection of whiskers in vivo in the whisker system of rodents.en_US
dc.identifierhttps://doi.org/10.13016/M2S17SS9Z
dc.identifier.urihttp://hdl.handle.net/1903/19759
dc.language.isoenen_US
dc.subject.pqcontrolledBiomedical engineeringen_US
dc.subject.pquncontrolledepidural anesthesiaen_US
dc.subject.pquncontrolledfunctional brain imagingen_US
dc.subject.pquncontrolledGradient refractive index (GRIN) lensen_US
dc.subject.pquncontrolledoptical coherence tomography (OCT)en_US
dc.subject.pquncontrolledvoltage-sensitive dye imaging (VSDi)en_US
dc.subject.pquncontrolledwhisker system of rodentsen_US
dc.titleNovel Endoscope for Surgical Guidance and Functional Brain Imagingen_US
dc.typeThesisen_US

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