Hyperpolarization-Activated Currents and Subthreshold Resonance in Granule Cells of the Olfactory Bulb

Simple item page
dc.contributor.authorHu, Ruilong
dc.contributor.authorFerguson, Katie A.
dc.contributor.authorWhiteus, Christina B.
dc.contributor.authorMeijer, Dimphna H.
dc.contributor.authorAraneda, Ricardo C.
dc.date.accessioned2017-08-31T19:53:12Z
dc.date.available2017-08-31T19:53:12Z
dc.date.issued2016-10-27
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.en_US
dc.description.abstractAn important contribution to neural circuit oscillatory dynamics is the ongoing activation and inactivation of hyperpolarization-activated currents (/h). Network synchrony dynamics play an important role in the initial processing of odor signals by the main olfactory bulb (MOB) and accessory olfactory bulb (AOB). In the mouse olfactory bulb, we show that /h is present in granule cells (GCs), the most prominent inhibitory neuron in the olfactory bulb, and that /h underlies subthreshold resonance in GCs. In accord with the properties of /h, the currents exhibited sensitivity to changes in extracellular K+ concentration and ZD7288 (4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidin chloride), a blocker of /h. ZD7288 also caused GCs to hyperpolarize and increase their input resistance, suggesting that /h is active at rest in GCs. The inclusion of cAMP in the intracellular solution shifted the activation of /h to less negative potentials in the MOB, but not in the AOB, suggesting that channels with different subunit composition mediate /h in these regions. Furthermore, we show that mature GCs exhibit /h-dependent subthreshold resonance in the theta frequency range (4–12 Hz). Another inhibitory subtype in the MOB, the periglomerular cells, exhibited /h-dependent subthreshold resonance in the delta range (1–4 Hz), while principal neurons, the mitral cells, do not exhibit /h-dependent subthreshold resonance. Importantly, /h size, as well as the strength and frequency of resonance in GCs, exhibited a postnatal developmental progression, suggesting that this development of /h in GCs may differentially contribute to their integration of sensory input and contribution to oscillatory circuit dynamics.en_US
dc.identifierhttps://doi.org/10.13016/M2ZG6G72B
dc.identifier.citationeNeuro 27 October 2016, 3 (5) ENEURO.0197-16.2016; DOI: https://doi.org/10.1523/ENEURO.0197-16.2016en_US
dc.identifier.urihttp://hdl.handle.net/1903/19706
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtBiologyen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectgranule cellen_US
dc.subjectHCNen_US
dc.subjectneurogenesisen_US
dc.subjectolfactory bulben_US
dc.subjectresonanceen_US
dc.titleHyperpolarization-Activated Currents and Subthreshold Resonance in Granule Cells of the Olfactory Bulben_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ENEURO.0197-16.2016.full.pdf
Size:
1.71 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Biology Research Works