Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1

Simple item page
dc.contributor.authorSordillo, Joanne E
dc.contributor.authorSharma, Sunita
dc.contributor.authorPoon, Audrey
dc.contributor.authorLasky-Su, Jessica
dc.contributor.authorBelanger, Kathleen
dc.contributor.authorMilton, Donald K
dc.contributor.authorBracken, Michael B
dc.contributor.authorTriche, Elizabeth W
dc.contributor.authorLeaderer, Brian P
dc.contributor.authorGold, Diane R
dc.contributor.authorLitonjua, Augusto A
dc.date.accessioned2021-11-01T19:33:58Z
dc.date.available2021-11-01T19:33:58Z
dc.date.issued2011-12-08
dc.description.abstractPolymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in children. In a previous analysis of 372 children from the Boston Home Allergens and the Connecticut Childhood Asthma studies, 7 SNPs in 6 genes (CARD15, TGFB1, LY96, ACAA1, DEFB1 and IFNG) involved in innate immune pathways were associated with asthma, and 5 SNPs in 3 genes (CD80, STAT4, IRAK2) were associated with eczema. We tested these SNPs for interaction with early life endotoxin exposure (n = 291), in models for asthma and eczema by age 6. We found a significant interaction between endotoxin and a SNP (rs156265) in ACAA1 (p = 0.0013 for interaction). Increased endotoxin exposure (by quartile) showed protective effects for asthma in individuals with at least one copy of the minor allele (OR = 0.39 per quartile increase in endotoxin, 95% CI 0.15 to 1.01). Endotoxin exposure did not reduce the risk of asthma in children homozygous for the major allele. Our findings suggest that protective effects of endotoxin exposure on asthma may vary depending upon the presence or absence of a polymorphism in ACAA1.en_US
dc.description.urihttps://doi.org/10.1186/1471-2350-12-158
dc.identifierhttps://doi.org/10.13016/l4p5-xccd
dc.identifier.citationSordillo, J.E., Sharma, S., Poon, A. et al. Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1. BMC Med Genet 12, 158 (2011).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28078
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtSchool of Public Health
dc.relation.isAvailableAtMaryland Institute of Applied Environmental Health
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectAsthmaen_US
dc.subjectAllergic Diseaseen_US
dc.subjectEndotoxin Levelen_US
dc.subjectAsthma Risken_US
dc.subjectDominant Genetic Modelen_US
dc.titleEffects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1471-2350-12-158.pdf
Size:
723.98 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Global, Environmental, and Occupational Health Research Works