The Role of Lipid Metabolism in B Cell Immune Functions

dc.contributor.advisorSong, Wenxia
dc.contributor.authorBeher, Richa
dc.date.accessioned2020-04-26T20:43:59Z
dc.date.available2020-04-26T20:43:59Z
dc.date.issued2020
dc.description.abstractEvidence indicates that lipid accumulation due to obesity triggers a low-grade, chronic inflammation, which is correlated with the occurrence of Type 2 diabetes (T2D). Recent studies provide evidence for the essential role that B cells play in obesity-induced inflammation and the development of insulin resistance. In visceral adipose tissue (VAT), B cells generate self-reactive antibodies (autoantibodies), which increase their pathogenicity. They also activate the production of cytokines by T cells through antigen presentation. Lastly, B cells themselves increase the production of inflammatory cytokines while decreasing the production of the anti-inflammatory cytokine IL-10. We hypothesize that neutral lipid accumulation exclusively in B cells will cause them to infiltrate VAT, trigger autoantibody production, and develop an autoimmune pathology. Preliminary research has led to the generation of a B cell-specific CGI-58 knockout (BKO) mice model in order to induce neutral lipid accumulation in B cells. It was found that increased accumulation of triglycerides in CGI-58 BKO mice significantly increased the levels of spontaneous activation in B cells, shown by the increases in the number of germinal center B cells, the surface expression levels of B cell activation markers, and the number of infiltrated lymphocytes in VAT, compared to Flox controls. The goal of this project is to determine the mechanism by which B cell lipid metabolism regulates B cell activation and pathogenicity in obesity-associated insulin resistance.en_US
dc.description.sponsorshipMaryland Summer Scholars Programen_US
dc.identifierhttps://doi.org/10.13016/i7ir-7pij
dc.identifier.urihttp://hdl.handle.net/1903/25885
dc.language.isoen_USen_US
dc.relation.isAvailableAtMaryland Center for Undergraduate Research
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectCBMGen_US
dc.subjectCMNSen_US
dc.subjectBeheren_US
dc.subjectB cell immunologyen_US
dc.subjectLipid metabolismen_US
dc.subjectObesity-related insulin resistanceen_US
dc.titleThe Role of Lipid Metabolism in B Cell Immune Functionsen_US
dc.typePresentationen_US

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