NOVEL GRAPHENE HETEROSTRUCTURES FOR SENSITIVE ENVIRONMENTAL AND BIOLOGICAL SENSING

Abstract

The COVID-19 pandemic has underscored the need for rapid, mobile, and adaptable sensing platforms to respond swiftly to pandemic-level emergencies. Additionally, smog and volatile organic compounds (VOCs), which posed significant health risks during last year’s wildfires, highlight the critical need for environmental air quality monitoring. Graphene, with its high sensitivity and fast response times, shows promise as a powerful sensing platform. However, it faces challenges related to low selectivity and the complexities of device fabrication using conventional chemical vapor-deposited graphene grown on metal foil, which requires exfoliation and transfer to suitable substrates.This dissertation explores the use of epitaxial graphene, which is graphene grown from the sublimation of silicon from silicon carbide, and forming heterostructures with legacy functional materials, such as transition metal oxides and selective capture probes like antibodies and aptamers to develop rapid, ultrasensitive, and selective sensors to address critical environmental and public health challenges. Epitaxial graphene provides a single-crystal, lithography-compatible graphene substrate that retains the desirable electronic properties of graphene without the drawbacks associated with transferred materials. This work focuses on creating heterostructures using traditional functional materials, such as manganese dioxide and antibodies, to develop high-quality, selective sensors for both biological and environmental applications. The practical applications of these sensors are demonstrated and validated using techniques such as Raman spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, and electrical characterization. Additionally, detailed material analysis on producing these heterostructures is provided, emphasizing their ability to be modified without damaging the underlying graphene surface. This highlights epitaxial graphene's robust and versatile nature and its potential for creating high-quality devices with relatively simple designs. Finally, these biosensors are applied to alternate antibody-antigen systems, including influenza, to enhance disease-tracking capabilities. We also explore advanced functional materials, such as protease-peptide systems, which enable the creation of on-chip chemistry systems previously unattainable with current material systems.