Relationship between physical activity and telomere maintenance in peripheral blood mononucleocytes

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dc.contributor.advisorRoth, Stephen Men_US
dc.contributor.authorLudlow, Andrew Todden_US
dc.contributor.departmentKinesiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2007-09-28T14:58:52Z
dc.date.available2007-09-28T14:58:52Z
dc.date.issued2007-07-24en_US
dc.description.abstractThe purpose of this study was to examine the relationship between exercise energy expenditure (EEE) and telomere length, telomerase activity, and hTERT genotype. Sixty-nine male (n = 34) and female (n = 35) participants 50-70 yr. were assessed for weekly EEE level using the Yale Physical Activity Survey. Subjects were grouped according to EEE. Telomere length and telomerase activity were measured in peripheral blood mononuclear cells (PBMCs). Relative telomere length was significantly higher in the Middle EEE group compared to both the low and high EEE groups (p<0.05). Telomerase activity was not different among the three EEE groups. The TT hTERT genotype had significantly greater telomerase enzyme activity than both the CT and CC genotypes (P = 0.013). In conclusion, moderate exercise energy expenditure levels may provide a protective effect on PBMC telomere length compared to both low and high EEE levels. hTERT genotype was associated with telomerase activity.en_US
dc.format.extent1574205 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/7245
dc.language.isoen_US
dc.subject.pqcontrolledHealth Sciences, Epidemiologyen_US
dc.subject.pqcontrolledBiology, Cellen_US
dc.subject.pqcontrolledGerontologyen_US
dc.subject.pquncontrolledTelomereen_US
dc.subject.pquncontrolledTelomeraseen_US
dc.subject.pquncontrolledPhysical Activityen_US
dc.subject.pquncontrolledExerciseen_US
dc.subject.pquncontrolledhTERTen_US
dc.subject.pquncontrolledAgingen_US
dc.titleRelationship between physical activity and telomere maintenance in peripheral blood mononucleocytesen_US
dc.typeThesisen_US

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