Regulation of glutamine utilization during T cell activation

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dc.contributor.advisorFrauwirth, Kennethen_US
dc.contributor.authorCarr, Erikka Lynnetteen_US
dc.contributor.departmentCell Biology & Molecular Geneticsen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2007-09-28T15:03:10Z
dc.date.available2007-09-28T15:03:10Z
dc.date.issued2007-08-13en_US
dc.description.abstractActivation of a naïve T cell is a highly energetic event, which requires an increase in metabolism. Upon stimulation, T cells increase in size, rapidly proliferate and differentiate, all of which lead to a high demand for energetic and biosynthetic precursors. Even though amino acids are the basic building blocks of protein biosynthesis, the role of amino acid metabolism in this process has not been well characterized. We have found that glutamine in particular is required for both proliferative as well as effector function. We have evidence that glutamine regulates ERK signaling and that ERK in turn may also regulate glutamine transport. These data indicate that glutamine may play a significant role in T cell signaling and that a better understanding of glutamine utilization in T cells may reveal novel targets for immunomodulatory and/or anti-leukemia therapy.en_US
dc.format.extent679662 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/7395
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pqcontrolledBiology, Cellen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pquncontrolledglutamine metabolismen_US
dc.subject.pquncontrolledT cell activationen_US
dc.subject.pquncontrolledmetabolismen_US
dc.subject.pquncontrolledamino acid utilizationen_US
dc.titleRegulation of glutamine utilization during T cell activationen_US
dc.typeThesisen_US

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