Therapeutic Potential of RNAi Through Endocytotic Methods

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dc.contributor.advisorDinman, Jonathan
dc.contributor.authorDong, Joe
dc.contributor.authorGiromini, Christopher
dc.contributor.authorHan, Woojin
dc.contributor.authorHatten, Sonja
dc.contributor.authorKim, Ki
dc.contributor.authorPahlavan, Autusa
dc.contributor.authorPatel, Rajan
dc.contributor.authorUfot, Ani
dc.contributor.authorYoung, LeAnne
dc.date.accessioned2016-06-09T18:22:31Z
dc.date.available2016-06-09T18:22:31Z
dc.date.issued2016-05
dc.description.abstractThe ability to manipulate gene expression promises to be an important tool for the management of infectious diseases and genetic disorders. However, a major limitation to effective delivery of therapeutic RNA to living cells is the cellular toxicity of conventional techniques. Team PANACEA’s research objective was to create new reagents based on a novel small-molecule delivery system that uses a modular recombinant protein vehicle consisting of a specific ligand coupled to a Hepatitis B Virus-derived RNA binding domain (HBV-RBD). Two such recombinant delivery proteins were developed: one composed of Interleukin-8, the other consisting of the Machupo Virus GP1 protein. The ability of these proteins to deliver RNA to cells were then tested. The non-toxic nature of this technology has the potential to overcome limitations of current methods and could provide a platform for the expansion of personalized medicine.en_US
dc.identifierhttps://doi.org/10.13016/M2NR2W
dc.identifier.urihttp://hdl.handle.net/1903/18083
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team PANACEA: Promoting A Novel Approach to Cellular (gene) Expression Alterationen_US
dc.subjectRNA interferenceen_US
dc.subjectRNAien_US
dc.titleTherapeutic Potential of RNAi Through Endocytotic Methodsen_US
dc.typeThesisen_US

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