A Novel Cyclic Acetal Biomaterial and Its Use in Cleft Palate Repair

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dc.contributor.advisorFisher, John Pen_US
dc.contributor.authorMoreau, Jennifer Lynnen_US
dc.contributor.departmentChemical Engineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2006-06-14T06:01:42Z
dc.date.available2006-06-14T06:01:42Z
dc.date.issued2006-05-04en_US
dc.description.abstractCleft lip and/or palate are the most prevalent congenital craniofacial birth defect in humans. While myriad surgical techniques have been described to repair orofacial clefts, several complications have been associated with the repair techniques. To overcome these complications, a tissue engineering strategy may be employed. In particular, we are investigating strategies for regenerating the alveolar bone that is often missing as a result of cleft palates. Numerous materials have been explored as biomaterials for bone tissue engineering, however there are disadvantages to these, including compromised mechanical properties and harmful degradation products. To overcome this issue, a novel class of biomaterials has been created. These materials are crosslinked networks of monomers of 5-ethyl-5-(hydroxymethyl)-beta,beta-dimethyl-1,3-dioxane-2-ethanol diacrylate. The study presented here was designed to determine the effects of the material's formulation scheme on several of its physical properties, so as to develop a novel bone tissue engineering material suitable for cleft palate repair.en_US
dc.format.extent595510 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/3561
dc.language.isoen_US
dc.subject.pqcontrolledEngineering, Chemicalen_US
dc.subject.pquncontrolledbiomaterialsen_US
dc.subject.pquncontrolledtissue engineeringen_US
dc.subject.pquncontrolledcleft palateen_US
dc.titleA Novel Cyclic Acetal Biomaterial and Its Use in Cleft Palate Repairen_US
dc.typeThesisen_US

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