Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark

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dc.contributor.authorPoulsen, Aslak Harbo
dc.contributor.authorHvidtfeldt, Ulla Arthur
dc.contributor.authorSørensen, Mette
dc.contributor.authorPuett, Robin
dc.contributor.authorKetzel, Matthias
dc.contributor.authorBrandt, Jørgen
dc.contributor.authorGeels, Camilla
dc.contributor.authorChristensen, Jesper H.
dc.contributor.authorRaaschou-Nielsen, Ole
dc.date.accessioned2021-04-01T19:41:11Z
dc.date.available2021-04-01T19:41:11Z
dc.date.issued2020-07-08
dc.description.abstractInconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10-year mean residential outdoor exposure to particulate matter < 2.5 μm (PM2.5), nitrous oxides (NOX), primary emitted black carbon (BC) and ozone. We used conditional logistic regression to calculate odds ratios (OR) linearly (per interquartile range (IQR)) and categorically. We accounted for personal income, employment, marital status, use of medication as well as socio-demographic conditions at area level. Malignant tumors of the intracranial CNS was associated with BC (OR: 1.034, 95%CI: 1.005–1.065 per IQR. For NOx the OR per IQR was 1.026 (95%CI: 0.998–1.056). For malignant non-glioma tumors of the brain we found associations with PM2.5 (OR: 1.267, 95%CI: 1.053–1.524 per IQR), BC (OR: 1.049, 95%CI: 0.996–1.106) and NOx (OR: 1.051, 95% CI: 0.996–1.110). Our results suggest that air pollution is associated with malignant intracranial CNS tumors and malignant non-glioma of the brain. However, additional studies are needed.en_US
dc.description.urihttps://doi.org/10.1186/s12940-020-00631-9
dc.identifierhttps://doi.org/10.13016/y2rf-75lz
dc.identifier.citationPoulsen, A.H., Hvidtfeldt, U.A., Sørensen, M. et al. Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark. Environ Health 19, 81 (2020).en_US
dc.identifier.urihttp://hdl.handle.net/1903/26939
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtSchool of Public Health
dc.relation.isAvailableAtMaryland Institute of Applied Environmental Health
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectEpidemiologyen_US
dc.subjectAir pollutionen_US
dc.subjectRegister studyen_US
dc.subjectCNS-tumorsen_US
dc.titleIntracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmarken_US
dc.typeArticleen_US

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