Orbitofrontal Cortex Modulates Auditory Cortical Sensitivity and Sound Perception in Mongolian gerbils

Macedo-Lima, Matheus; Hamlette, Lashaka Sierra

Orbitofrontal Cortex Modulates Auditory Cortical Sensitivity and Sound Perception in Mongolian gerbils

dc.contributor.advisor	Caras, Melissa L.
dc.contributor.author	Macedo-Lima, Matheus
dc.contributor.author	Hamlette, Lashaka Sierra
dc.date.accessioned	2024-06-06T14:59:03Z
dc.date.available	2024-06-06T14:59:03Z
dc.date.issued	2024
dc.description	This dataset includes preprocessed data from the following techniques: - Electrophysiology - Fiber photometry - Behavior Analysis pipeline can be found in: https://github.com/caraslab/MacedoLima_CurBiol2024
dc.description.abstract	Sensory perception is dynamic, quickly adapting to sudden shifts in environmental or behavioral context. Though decades of work have established that these dynamics are mediated by rapid fluctuations in sensory cortical activity, we have a limited understanding of the brain regions and pathways that orchestrate these changes. Neurons in the orbitofrontal cortex (OFC) encode contextual information, and recent data suggest that some of these signals are transmitted to sensory cortices. Whether and how these signals shape sensory encoding and perceptual sensitivity remains uncertain. Here, we asked whether the OFC mediates context-dependent changes in auditory cortical sensitivity and sound perception by monitoring and manipulating OFC activity in freely moving Mongolian gerbils of both sexes under two behavioral contexts: passive sound exposure and engagement in an amplitude modulation (AM) detection task. We found that the majority of OFC neurons, including the specific subset that innervate the auditory cortex, were strongly modulated by task engagement. Pharmacological inactivation of the OFC prevented rapid context-dependent changes in auditory cortical firing, and significantly impaired behavioral AM detection. Our findings suggest that contextual information from the OFC mediates rapid plasticity in the auditory cortex and facilitates the perception of behaviorally relevant sounds.
dc.description.sponsorship	Purchase of the Zeiss LSM 980 Airyscan 2 was supported by Award Number 1S10OD025223-01A1 from the National Institutes of Health (NIH). This work was supported by NIH R00DC016046 and R01DC020742.
dc.identifier	https://doi.org/10.13016/qzzx-zfuh
dc.identifier.uri	http://hdl.handle.net/1903/32599
dc.language.iso	en_US
dc.publisher	Current Biology
dc.relation.isAvailableAt	College of Computer, Mathematical & Physical Sciences	en_us
dc.relation.isAvailableAt	Digital Repository at the University of Maryland	en_us
dc.relation.isAvailableAt	Biology	en_us
dc.relation.isAvailableAt	University of Maryland (College Park, MD)	en_us
dc.subject	attention
dc.subject	prefrontal cortex
dc.subject	top-down
dc.subject	cortical plasticity
dc.subject	behavioral context
dc.title	Orbitofrontal Cortex Modulates Auditory Cortical Sensitivity and Sound Perception in Mongolian gerbils
dc.type	Dataset
local.equitableAccessSubmission	No