Orbitofrontal Cortex Modulates Auditory Cortical Sensitivity and Sound Perception in Mongolian gerbils

dc.contributor.advisorCaras, Melissa L.
dc.contributor.authorMacedo-Lima, Matheus
dc.contributor.authorHamlette, Lashaka Sierra
dc.date.accessioned2024-06-06T14:59:03Z
dc.date.available2024-06-06T14:59:03Z
dc.date.issued2024
dc.descriptionThis dataset includes preprocessed data from the following techniques: - Electrophysiology - Fiber photometry - Behavior Analysis pipeline can be found in: https://github.com/caraslab/MacedoLima_CurBiol2024
dc.description.abstractSensory perception is dynamic, quickly adapting to sudden shifts in environmental or behavioral context. Though decades of work have established that these dynamics are mediated by rapid fluctuations in sensory cortical activity, we have a limited understanding of the brain regions and pathways that orchestrate these changes. Neurons in the orbitofrontal cortex (OFC) encode contextual information, and recent data suggest that some of these signals are transmitted to sensory cortices. Whether and how these signals shape sensory encoding and perceptual sensitivity remains uncertain. Here, we asked whether the OFC mediates context-dependent changes in auditory cortical sensitivity and sound perception by monitoring and manipulating OFC activity in freely moving Mongolian gerbils of both sexes under two behavioral contexts: passive sound exposure and engagement in an amplitude modulation (AM) detection task. We found that the majority of OFC neurons, including the specific subset that innervate the auditory cortex, were strongly modulated by task engagement. Pharmacological inactivation of the OFC prevented rapid context-dependent changes in auditory cortical firing, and significantly impaired behavioral AM detection. Our findings suggest that contextual information from the OFC mediates rapid plasticity in the auditory cortex and facilitates the perception of behaviorally relevant sounds.
dc.description.sponsorshipPurchase of the Zeiss LSM 980 Airyscan 2 was supported by Award Number 1S10OD025223-01A1 from the National Institutes of Health (NIH). This work was supported by NIH R00DC016046 and R01DC020742.
dc.identifierhttps://doi.org/10.13016/qzzx-zfuh
dc.identifier.urihttp://hdl.handle.net/1903/32599
dc.language.isoen_US
dc.publisherCurrent Biology
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtBiologyen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectattention
dc.subjectprefrontal cortex
dc.subjecttop-down
dc.subjectcortical plasticity
dc.subjectbehavioral context
dc.titleOrbitofrontal Cortex Modulates Auditory Cortical Sensitivity and Sound Perception in Mongolian gerbils
dc.typeDataset
local.equitableAccessSubmissionNo

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